Colorectal cancer (CRC) is the third most common worldwide and second cause of cancer-related death. The incidence early-onset CRC in those younger than 50 years rising globally. In this group, absence high-risk features screening not standard care. There strong evidence that development related to diet lifestyle. Retrospective, unicentric, cohort analysis patients with rectal diagnosed between...

Background: Ruptured Intracranial Infected Aneurysms (IIAs) are relatively rare, but they portend high mortality. To our knowledge, there no Canadian case-series on IIA, as well is a relative paucity of international published experiences. Our purpose to share the experience single tertiary centre in managing ruptured IIA and conduct systematic review. Methods: We did retrospective case review ...

The p-center problem is a well-known and highly studied pertaining to the identification of p potential n center locations in such way as minimize maximum distance between users closest center. As opposed p-center, p-second minimizes sum distances from second centers. In this paper, we propose new Variable Neighborhood Search based algorithm for solving problem. Its performance assessed on benc...