the synthesis and properties of new monoazo dyes derived from the diazonium salts of paminobenzoic acid, 3-trifluoromethyl aniline , 4-trifluoromethyl aniline are considered .theprepared compounds were characterized by uv-visible , ft-ir and h nmr spectroscopictechniques . the effect of varying solvent upon the absorption ability of p-amino benzoic acidcoupled with 4,4 —diethyl aniline , anilin...

Previously, we established a method to assess drug metabolism capacity based on a pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP-test) by introducing an apparent liver-to-blood free concentration gradient in vivo (qg). The qg values were determined as the ratio of in vivo-in vitro clearance. In this study, we examined the application of the PKCYP-test to the ...

The urinary metabolites of 3-methyl-4-trifluoromethylaniline in the rat were characterized and quantified using a combination of (19)F NMR, HPLC-NMR ((1)H and (19)F), and HPLC-mass spectrometry techniques. The major routes of metabolism were amine N-acetylation and methyl group C-oxidation to the benzyl alcohol (with subsequent glucuronide conjugation) and further to the corresponding benzoic a...

Here we report the successful room temperature synthesis of zirconium phosphate nanoparticles (ZPNP) using the P123 tri-co-block polymer for the first time. The samples were characterized by SEM, TEM, XRD, TPD, and BET and were employed for fixation of CO2 on aniline to produce pharmaceutically important acetanilide under mild reaction conditions (150 °C and 150 Psi CO2 pressure).

Enzymic depletion of glutathione (GSH) in vitro by aniline analogs was mostly dependent on the cytochrome P-450 level in liver microsomes. In a case of acetaminophen (AAP), active metabolite of AAP formed through liver microsomal drug metabolizing enzymes consumed GSH. The active metabolite formed binds, at least in part, covalently to liver microsomal proteins. In addition, species differences...