Introduction: Worldwide, >200 million patients are affected by peripheral arterial disease (PAD) and endovascular interventional treatments increasingly being applied. Contrast-induced nephropathy (CIN) is the third most common cause of renal failure in hospitals. However, factors such as vasoconstriction, decrease blood flow, endothelial dysfunction, oxidative stress have been suggested...

BACKGROUND Recently, a demand for safe and effective treatment of acne has been increasing. Although visible light has attracted attention as a new option, the effect of red light alone has not yet been evaluated. OBJECTIVES The objective was to assess the efficacy of red light phototherapy with a portable device in acne vulgaris. METHODS Twenty-eight volunteers with mild to moderate acne w...

Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

The effects on haemodynamics and infarct size (measured by total creatine kinase release) of intravenous infusions of normal saline, glucose, or glucose-insulin-potassium were studied in 36 patients with transmural acute myocardial infarction qf less than 12 hours' duration. In 12 patients, 2 ml/kg 50 per cent glucose (5.55 mmol/kg) was given over 10 minutes with 0 4 unit/kg soluble insulin 5 m...

The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 6.5 years. A subset of these subjects gained excessive weight. We tested for association of polymorphisms in 8 candidate genes with the above trait. We found the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor ...

S ince the first big landmark trial on glycemic control and complications in type 1 diabetes (DCCT [Diabetes Control and Complications Trial]) 1 was published in 1993, almost every major trial for type 1 and type 2 diabetes has consistently demonstrated the beneficial effects of lowering glucose on diabetes complications. According to large randomized trials, there is no question that the lower...

Recent studies suggest the potential of alpha-tocopherol as a gene regulator, possibly through peroxisome proliferator-activated receptor gamma (PPARgamma) activation due to the structural similarity of alpha-tocopherol to a PPARgamma ligand, troglitazone. Other investigators have suggested that a link exists between induction of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD) and cata...

BACKGROUND This post hoc subanalysis examined outcomes in adult patients with Morquio A (mucopolysaccharidosis IVA) who received enzyme replacement therapy (ERT) with elosulfase alfa over a 120-weeks period. Patients ≥18 years of age evaluated in an open-label, long-term extension study of elosulfase alfa (modified per protocol [MPP], n = 32; intent-to-treat [ITT], n = 37; MOR-005; NCT01415427)...

Background Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in patients with during the course disease. Among BPSD symptoms, agitation aggression a source distress for both their caregivers. In this study, we investigated impact on Quality Life (QoL) living long-term care homes or admitted to psychiatric inpatient units. Method Data were obtained from Standardizing ...