The use of Oxone and a palladium(II) catalyst enables the efficient allylic CH oxidation of sterically hindered α-quaternary lactams which are unreactive under known conditions for similar transformations. This simple, safe, and effective system for CH activation allows for unusual tunable selectivity between a two-electron oxidation to the allylic acetates and a four-electron oxidation to th...

Various 1-arylbenziodoxolones can be conveniently prepared from 2-iodobenzoic acid and arenes by a one-pot procedure using Oxone (2KHSO5·KHSO4·K2SO4) as an inexpensive and environmentally safe oxidant. This procedure is also applicable for the synthesis of the 7-methylbenziodoxolone ring system using 2-iodo-3-methylbenzoic acid as starting compound. Structures of four 1-arylbenziodoxolone deriv...

The methyl diazoacetate and aryl (N-tosyl)imines can be transformed into syn or anti a-hydroxy b-amino esters with high diastereoselectivities in three steps: the base promoted nucleophilic condensation of the methyl diazoacetate and aryl (N-tosyl)imines to give b-(N-tosyl)amino a-diazoesters, followed by oxidation with Oxone to generate a-oxo esters, which were reduced with NaBH4 to yield the ...

A convenient and efficient [3 + 2] cycloaddition reaction of alkenes alkynes with the in situ generated nitrile oxides from aldoximes presence NaCl, Oxone Na2CO3 has been developed to afford a series isoxazoles isoxazolines at room temperature yields up 85% 86%, respectively. The current methodology exhibits wide substrate scope, (hetero)aromatic aliphatic aldoximes, including acrylate esters, ...

Herein, we report a new method of synthesis N-acylureas (E1–5) via reaction dibenzoylhydrazine carboxamide (N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide) (C) and various benzylamines. Preparation was performed by the treatment 5,6-diaryl-3-methylthio-1,2,4-triazine (B) with Oxone which leads to oxidation triazine ring cleavage in high yield (82%). Five benzylamine derivatives containing dif...

A novel approach to the preparation of imidazole-substituted cyclic iodonium salts has been developed via oxidative cyclization 1-phenyl-5-iodoimidazole using a cheap and available Oxone/H2SO4 system. The structure new polycyclic heteroarenes confirmed by single-crystal X-ray diffractometry, revealing characteristic features for salts. newly produced imidazole-flanked compounds were found readi...