Little is known about the molecular basis for differential pulmonary oxidant sensitivity observed between genetically disparate members of the same species. We have generated mice that are deficient in Clara cell secretory protein (CCSP -/-) and that exhibit an oxidant-sensitive phenotype. We characterized the kinetics and distribution of altered stress-response [interleukin-6 (IL-6) and metall...

Of the several factors believed to exacerbate asthmatic symptoms, air pollution and viral infections are considered to be particularly important. Although evidence indicates that each of these respiratory insults individually can increase asthma severity in susceptible individuals, we know little about the extent to which exposure to environmental oxidant pollutants can influence the course of ...

We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Oxidative stress induced an early (10 minutes) mitochondrial DNA damage, and concomitant activation of PARP1 in the mitochondria. These early events were followed by a progressive mitochondrial...

We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Oxidative stress induced an early (10 minutes) mitochondrial DNA damage, and concomitant activation of PARP1 in the mitochondria. These early events were followed by a progressive mitochondrial...

Rahman, Arshad, Khandaker N. Anwar, and Asrar B. Malik. Protein kinase C-z mediates TNF-a-induced ICAM-1 gene transcription in endothelial cells. Am J Physiol Cell Physiol 279: C906–C914, 2000.—We addressed the role of protein kinase C (PKC) isozymes in mediating tumor necrosis factor-a (TNF-a)-induced oxidant generation in endothelial cells, a requirement for nuclear factor-kB (NF-kB) activati...

Nanomaterials are capable of generating reactive oxygen species (ROS) due to defect-induced electronic interactions with and water stimulated by environmental structural factors (e.g., photonic energy, band edge morphology) resulting in excellent pro-oxidant activity nanomaterials. The activities demonstrated the antibacterial nanomaterials under different conditions varying light levels). This...

Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized link between these processes and oxidant stress is via alterations in Ca(2+) signaling. However, precisely how oxidants influence Ca(2+) signaling remains unclear. Oxidant stress led to a phenotypic shift in Ca(2+) mobilization from an oscillatory to a sustained elevated ...

Earlier works have revealed increased generation of reactive oxygen species (ROS) and decreased antioxidant levels in type 1 diabetes mellitus (T1DM). The current study aimed to investigate the effect mixed insulin therapy on oxidative stress status patients with T1DM. This involved 75 participants who were divided into three groups: 20 healthy subjects as a control, 25 newly diagnosed T1DM (wi...

for the first time, dioxomolybdenum(vi) complex with the general formula [moo2l2] containing a n-o bidentate ligands (hl=2-(o-aminophenyl)- benzimidazole) has been used for the oxidation of sulfides. elemental analyses (carbon, hydrogen, nitrogen), ft-ir and uv-visble spectra and 1hnmr analysis agree well with the proposed stoicheiometry of the complex [moo2l2].  a variety of sulfides were smoo...