Clostridium difficile infection (CDI) is a potential life-threatening consequence of antibiotic therapy. Although the risk increases with duration of treatment, it can also occur after a short treatment course. In addition to broad-spectrum antibiotics, anti-neoplastic agents, proton pump inhibitors, H(2) blockers, and several other drugs have been reported to induce intestinal dysbiosis, which...

25 Cadazolid is a new oxazolidinone-type antibiotic currently in clinical development 26 for the treatment of Clostridium difficile-associated diarrhea. Here we report 27 investigations on the mode of action and the propensity for spontaneous resistance 28 development in C. difficile strains. Macromolecular labeling experiments indicated that 29 cadazolid acts as a potent inhibitor of protein s...

In the title compound, C(19)H(19)BrN(2)O(2)S, the central thieno-pyrim-idine ring system is essentially planar, with a maximum displacement of 0.068 (3) Å. The attached cyclo-hexene ring adopts a half-chair conformation. The molecular conformation and crystal packing are stabilized by three intra-molecular C-H⋯O hydrogen bonds and two C-H⋯π inter-actions.

Physical and chemical quenching rate constants were measured for the reaction of singlet oxygen with oxazolidinone-functionalized enecarbamates to investigate the role of vibrational deactivation in product stereoselectivity.

Nucleophilic addition of the chiral lithium enolates of (S)-(−)-4-benzyl-2-oxazolidinone acetamide with N-tosyl arylaldehyde imines gives -aryl-amino acid derivatives in good yields and excellent diastereoselectivity. © 2002 Elsevier Science Ltd. All rights reserved. -Amino acids and their derivatives have attracted considerable attention in recent years due to their occurrence in biologically ...

Oxazolidinone-substituted enecarbamates offer a system to explore vibrational quenching and the strategic placement of CH bonds as a method for manipulating the stereoselectivity of photoreactions.

The preparation of oxazolidinones by the hypervalent iodine mediated cyclization allylcarbamates is described. A versatile range substrates can be converted into substituted primed for further transformations. Derivatization products at both ends demonstrated. preliminary attempt enantioselective formation an oxazolidinone using a chiral iodane also presented.