During the last half of the twentieth century, the argon-argon method of dating geologic rocks and formations became very popular. This method replaced K/Ar as the method of choice for many types of rocks. This paper explores the fundamental mathematics of the argon-argon dating method and evaluates the impact of the assumed date of the “standard sample” on the calculated argon-argon date. A me...

Investigators who study rickettsial diseases are interested in finding an animal highly susceptible to these diseases. The lack of such an animal has prompted the investigation of numerous animals and the use of various techniques to increase their susceptibility. This is well demonstrated in the literature concerning murine and epidemic typhus. Although the guinea pig, cotton rat, and mouse ar...

Four distinct binding modes for the interaction of Escherichia coli single-strand binding (SSB) protein with single-stranded (ss) DNA have been identified on the basis of quantitative titrations that monitor the quenching of the SSB protein fluorescence upon binding to the homopolynucleotide poly(dT) over a range of MgCl2 and NaCl concentrations at 25 and 37 degrees C. This is the first observa...

of ilcnlologous l)OIlc lll trrO\V to sulall illanlillals can confer 1)rotcctioil against otherwise lethal closes of radiation.”2 The mecilaflism of this Protection appears to be repopulation of tlit’ (larnagcd marrow by tile (lonor cells.ih These fillclings have suggested tilat 1)one n arro v hoinotransplantation Illigllt find a )plicatiOn Hi tile tilcral)v of hunlall racliatioii casualties or ...

This meta-analysis extends a previous review of the achievement effects of comprehensive school reform (CSR) programs (Borman, Hewes, Overman, & Brown, 2003). That meta-analysis observed significant effects of well endowed and well-researched programs, but it did not account for race/ethnicity. This article synthesizes 34 cohort or quasi-experimental outcomes of studies that incorporated the po...

A library of bidentate diols, as well as tridentate triols and aminodiols, derived from (+)-sabinol, was synthesized in a stereoselective manner. Sabinol was transformed into allylic trichloroacetamide via Overman rearrangement of the corresponding trichloroacetimidate. After changing the protecting group to Boc, the enamine was subjected to stereospecific dihydroxylation with OsO₄/NMO, resulti...

This meta-analysis extends a previous review of the achievement effects of comprehensive school reform (CSR) programs (Borman, Hewes, Overman, & Brown, 2003). That meta-analysis observed significant effects of well endowed and well-researched programs, but it did not account for race/ethnicity. This article synthesizes 34 cohort or quasi-experimental outcomes of studies that incorporated the po...

In the first description of the characteristic symptoms following severe physical trauma, Ambroise Pare in 1575 mentioned that the features of this condition are: flaccid, atonic musculature, cold sweat, feeble, quick pulse, unresponsiveness, and general indifference. Defects in nervous function are evidentfrom this description. In 1889, Crile (Crile and Lower, 1899) suggested from experimental...

During the past decades, building on the seminal contributions of Overman and Shibasaki, the asymmetric intramolecular Heck reaction has been successfully applied in natural product synthesis to install tertiary and quaternary stereocenters. In stark contrast, the intermolecular version of this asymmetric transformation has not reached the same level of development and its synthetic utility rem...

In the last years huge efforts have been made to develop new activation modes in order to synthesize complex scaffolds in an enantiopure form. The most common approach has been the development of new catalysts to activate an “unreactive” compound A that will react with a highly reactive compound B to render C. However, recently a new approach pushes the boundaries of organic chemistry: synergis...