When data are uniformly distributed, parallel hash-based join algorithm scales up well. However, the presence of data skew can cause load imbalance among the processors, significantly deteriorating its performance. In this paper we propose a dynamic skew handling algorithm which deals with this load imbalance, by detecting and handling join product skews at run-time. The idea is to monitor the ...

ÐIn this paper, we consider a new, session-based workload for measuring web server performance. We define a session as a sequence of client's individual requests. Using a simulation model, we show that an overloaded web server can experience a severe loss of throughput measured as a number of completed sessions compared against the server throughput measured in requests per second. Moreover, st...

Generic programming enables the programmer to define functions by induction on the structure of types. Defined once, such a generic function can be used to generate a specialized function for any user defined data type. Several ways to support generic programming in functional languages have been proposed, each with its own pros and cons. In this paper we describe a combination of two existing ...

The relative effects of chronic pressure overload and chronic volume overload on left ventricular diastolic chamber stiffness were examined using a combined hemodynamic and ultrasonic technique in 27 patients. The slope of the left ventricular pressure-diameter relation in late diastole was measured and found to be steep in the groups with pressure or volume overload (9.0 ± 1.8 mm Hg/mm for pre...

ROCH-RAMEL, FRANCOISE, J. DI~ZI, FRANGOISE CHOM~TY, PIERRETTE MICHOUD, AND G. PETERS. Disposal of large urea overloads by the rat kidney: a micropuncture study. Am. J. Physiol. 2 1 a(6) : 1524-1532. 1970.-In rats overloaded with urea, at plasma concentrations of 60-80 mM, the proximal fractional reabsorption of urea was not impaired, whereas the cortical tissue-to-plasma urea concentration rati...

Hypertrophy is a critical event in the onset of failure in chronically overloaded hearts. Focal adhesion kinase (FAK) has attracted particular attention as a mediator of hypertrophy induced by increased load. Here, we demonstrate increased expression and phosphorylation of FAK in the hypertrophic left ventricles (LVs) of aortic-banded mice. We used an RNA interference strategy to examine whethe...

To investigate how intercellular coupling can be changed during Ca2+ overloading of ventricular muscle, we studied Ca2+ signals in individual cells and the histochemistry of the major gap junction channel, connexin43 (Cx43), using multicellular preparations. Papillary muscles were obtained from guinea pig ventricles and loaded with rhod-2. Sequential Ca2+ images of surface cells were obtained w...

Furin is a proprotein convertase enzyme. In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis. Hepcidin deficiency is a component of several iron overload disorders, including β-thalassemia. Several studies have identified factors that repress hepcidin gene transcription in iron overload. However, the effect of iron overload on furin, a post...

Renal and lung fibrosis was characterized by the accumulation of collagen-immunoreactive mesenchymal cells expressing the intermediate filament protein nestin. The present study tested the hypothesis that nestin expression was increased in the hypertrophied/fibrotic left ventricle of suprarenal abdominal aorta constricted adult male Sprague-Dawley rats and induced in ventricular fibroblasts by ...

Vibrio vulnificus multiplies rapidly in host tissues under iron-overloaded conditions. To understand the effects of iron in the physiology of this pathogen, we performed a genome-wide transcriptional analysis of V. vulnificus growing at three different iron concentrations, i.e., iron-limiting [Trypticase soy broth with 1.5% NaCl (TSBS) plus ethylenediamine-di-(o-hydroxyphenylacetic) acid (EDDA)...