Objective(s): The major antibiotic efflux pump of Esherichia coli is AcrAB-TolC. The first part of the pump, AcrAB, is encoded by acrAB operon. The expression of this operon can be kept elevated by overexpression of an activator, MarA following inactivation of MarR and AcrR repressors due to mutation in encoding genes, marR and acrR, respectively. The aims of this research were to us...

Background. NK cells are imperative in spontaneous antitumor response of various cancers. Currently, lncRNAs considered important modulators the tumor microenvironment. This study investigated molecular mechanism by which mitotically associated long noncoding RNA (MANCR) controls killing effect on lung adenocarcinoma (LUAD) Methods. The interplay between MANCR and miRNA-30d-5p was analyzed bioi...

Psoriasis is a chronic autoimmune inflammatory disease caused by keratinocyte hyperproliferation and cell infiltration due to dysregulated immune system. Recently, the importance of epigenetic regulation has been increasingly recognized in psoriasis. However, few current studies have reported on mutual between lncRNA miRNA The main objective this study was explore role HSFY2-10:1/miR-145-5p/FN1...

Abstract Background Ovarian cancer is a prominent cause of mortality among women worldwide. A kinase anchor protein 12 (AKAP12) has been investigated, but its contribution to ovarian unclear. Objectives This study comprehensively investigates the role AKAP12 in proliferation by elucidating underlying mechanisms and functions. Methods We compared expression levels adjacent tissues. subsequently ...

Gastrin plays a vital role in the development and progression of gastric cancer (GC). Its expression is up-regulated GC tissues several cell lines. Yet, underlying mechanism remains to be investigated. Here, we aim investigate gastrin proliferation. Gastrin-overexpressing model was constructed using SGC7901 cells. Then differentially expressed proteins were identified by iTRAQ analysis. Next, u...

Insect herbivores use phytochemicals as signals to induce expression of their phytochemical-detoxifying cytochrome P450 monooxygenases (P450s). The regulatory cascades that transduce phytochemical enhanced P450s are the focus this review. At least seven signaling pathways, including RTK/MAPK, GPCR/CREB, GPCR/NF?B, ROS/CncC/Keap1, AhR/ARNT, cytosol NR, and nucleus-located may be involved in indu...

Abstract Objectives To explore the role of dual-specific phosphatase 1 (DUSP1) in proliferation, migration and invasion pancreatic cancer (PC). Methods TCGA GTEx databases were used to investigate relationship between DUSP1 expression prognosis PC patients. Expression efficiency was validated by qPCR western blotting. The proliferation SW1990 PANC-1 cells with overexpression or knockout detecte...

Cutaneous squamous cell carcinoma (cSCC) is the second most frequent form of skin cancer showing a rapidly increasing incidence worldwide. NTs mediate their effects through common neurotrophin receptor CD271 and tyrosine kinases family receptors (Trks). In skin, implicated in switch between stem early progenitors, while Trk survival. However, precise role NT cSCC still to be defined. Gene prote...

of apoptosis proteins, functions as a key regulator of apoptosis and cell proliferation. Overexpression of survivin has been implicated in several human cancers, including human hepatocellular carcinoma (HCC). Although several factors have been shown in vitro to upregulate survivin expression in cancer cells, the in vivo regulators of survivin in human hepatocarcinogenesis are largely unknown. ...