Objective Royal jelly (RJ) is a complementary diet widely used by traditional healers for the treatment of infertility. The aim of present study was to evaluate the effect of RJ on some reproductive parameters in immature female rats. MaterialsAndMethods In this experimental study, thirty two immature female rats (30-35gr) were divided into four groups (n=8 /group). Control group received 0.5 m...

Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship between melasma and polycystic ovarian disease and androgenic hormones. Patients and Methods: Th...

In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including hypothalamic GnRH neuronal network, pituitary gonadotropin secretion and ovarian follicle growth steroidogenesis. Several hormones neuropeptides or metabolites are important signals between balance reproduction. These sensors mediate their action on cells through specifi...

The aim of the present study was to understand the hormonal mechanisms behind the effect of high temperatures on reproductive function. It was proposed that high temperatures can directly alter production of ovarian hormones and/or the response of ovarian cells to hormonal stimulators. To examine this hypothesis, in the 1st series of experiments, we compared the release of progesterone (P4), es...

The aim of our study was to understand whether ovarian steroid hormones, and their response to the metabolic hormones leptin and IGF-I leptin, could be involved in the control of mink reproductive aging via changes in basal release of ovarian progesterone and estradiol. For this purpose, we compared the release of progesterone and estradiol by ovarian fragments isolated from young (yearlings) a...

BACKGROUND The role of estrogen and progesterone in ovarian carcinogenesis and the growth and survival of ovarian cancer cells is controversial. In this study, we tested the effects of various concentrations of estrogen and progesterone on the survival of an ovarian cancer cell line. METHODS The ovarian adenocarcinoma cell line, OC-117-VGH, is deficient in the following receptors: estrogen re...

BACKGROUND The ovarian reserve (number and quality of oocytes) is correlated with reproductive potential as well as somatic health, and is likely to have multiple genetic and environmental determinants. Several reproductive hormones are closely linked with the oocyte pool and thus can serve as surrogate markers of ovarian reserve. However, we know little about the underlying genes or genetic va...

The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate basic ovarian functions (proliferation, apoptosis, secretory activity of ovaria...