Background: Premature ovarian aging as evidenced by AMH levels less than 0.5 ng/ml is predictive of reduced success in management infertility. The most effective treatment vitro fertilization which not affordable or acceptable to our patients with low socioeconomic background. Intra-ovarian injection autologous platelet rich plasma (PRP) improves the reserve markers but it remains be seen wheth...

Autophagy is a conserved cellular self-digestion pathway for maintenance of homeostasis under basal and stressed conditions. Autophagy plays pivotal roles in the pathogenesis of many diseases, such as aging-related diseases, autoimmune diseases, cardiovascular diseases, and cancers. Of special note is that accumulating data suggest an intimate relationship between autophagy and ovarian carcinom...

When does (sexual) ageing begin? Ageing is the natural progression of changes in structure and function that occurs with the passage of time in the absence of known disease [1] Women experience reproductive aging (hypothalamicpituitary-ovarian axis) superimposed on chronological aging. Reproductive aging begins at birth, with the progressive destruction of the oocyte’s reserve, and proceeds as ...

The delay in childbearing is an important societal change contributing to an increasing incidence of subfertility. The prevailing concept of female reproductive ageing assumes that the decline of both quantity and quality of the oocyte/follicle pool determines an age-dependent loss of female fertility. There is an apparent discrepancy between the ability to maintain a regular ovulatory cycle pa...

The aim of our study was to understand whether ovarian steroid hormones, and their response to the metabolic hormones leptin and IGF-I leptin, could be involved in the control of mink reproductive aging via changes in basal release of ovarian progesterone and estradiol. For this purpose, we compared the release of progesterone and estradiol by ovarian fragments isolated from young (yearlings) a...

The early decline and loss of female fertility in humans and other species represents an evolutionary paradox. Despite being born with a vast stock of oocytes, females encounter an exhaustion of ovarian reserve and sterility half way through their natural lives. Female reproductive ageing has been proposed to proceed as an ongoing decline in ovarian reserve, determined by remaining ovarian foll...

BACKGROUND Tests to assess the change in ovarian reserve (OR) with age have been analysed only in monophasic or biphasic linear patterns. Our aim was to analyse an optimum curve that might define the relationship between different OR tests and age. METHODS A total of 81 regularly menstruating women without a history of infertility were included in this prospective study. On cycle day 3, antra...

The menopausal transition in human females, which is driven by a loss of cyclic ovarian function, occurs around age 50 and is thought to underlie the emergence of an array of health problems in aging women. Although mice do not undergo a true menopause, female mice exhibit ovarian failure long before death because of chronological age and subsequently develop many of the same age-associated hea...

Screening asymptomatic women in the general population for ‘early ovarian ageing’ will be more effective in highrisk groups. Recent findings support the hypothesis that women with polycystic ovaries (PCO) may have actually been born with a larger pool of resting follicles. The mechanism is almost certainly genetic and occurs in fetal life. If, as is widely accepted, the rate of depletion of the...

Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotypes similar to older women, we sought to understand the mechanisms of ovarian a...