Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcri...

Background and Aims: Expanded donor criteria poses increased risk for late phase complications such as fibrosis that lead to graft dysfunction in liver transplantation. There remains a need to elucidate the precise mechanisms of post-transplant liver damage in order to improve the long-term outcomes of marginal liver grafts. In this study, we aimed to examine the role of oval cells in fibrogeni...

The oval cells are thought to be the progeny of a liver stem cell compartment and strong evidence now exists indicating that these cells can participate in liver regeneration by differentiating into different hepatic lineages. To better understand the regulation of this process we have studied the expression of liver-enriched transcriptional factors (HNF1 alpha and HNF1 beta, HNF3 alpha, HNF3 b...

The performance of two evaporatively cooled heat exchangers is analysed, one has plain circular tubes while the other one has plain oval tubes. Both are investigated under similar operating conditions in relation to airflow rates and inlet hot water temperatures. The circular tube is 10 mm o.d., and the oval tube (axes ratio 3.085) is formed from an 18 mm o.d. circular tube whose perimeter is p...

We present observations at near-infrared wavelengths (1–5 lm) of Jupiter’s north polar region and Northern Red Oval (NN-LRS-1). The observations were taken with the near-infrared camera NIRC2 coupled to the adaptive optics system on the 10-mW.M. Keck Telescope on UT 21 August 2010. At 5-lm Jupiter’s disk reveals considerable structure, including small bright rings which appear to surround all s...

OBJECTIVE The aim of this study was to investigate the canal diameters in the apical roots of human teeth to determine prevalence and extent of long oval canals. STUDY DESIGN This investigation was carried out on 180 extracted human teeth, 20 for each tooth group. Each root was horizontally sectioned at 1, 2, 3, 4, and 5 mm from the apex. Canal diameters were measured with a measuring microsc...

Inspired by the recent results toward Birkhoff conjecture (a rigidity property of billiards in ellipses), we discuss two properties conics. The first one concerns symmetries an analog polar duality associated with oval, and second circle map oval pencils lines.

A perianal mass in a 15-year-old domestic shorthair cat with a history of a firm, painful swelling in the left ventrolateral perianal region was surgically excised and submitted for light microscopic evaluation. Histologically, this was a poorly demarcated, unencapsulated, multilobulated neoplasm that invaded surrounding perirectal skeletal muscle bundles. Lobules were composed of sheets and ac...

[1] The Hubble Space Telescope (HST) data set obtained over two campaigns in 2007 is used to determine the long-term variability of the different components of Jupiter’s auroras. Three regions on the planet’s disc are defined: the main oval, the low-latitude auroras, and the high-latitude auroras. The UVauroral power emitted from these regions is extracted and compared to estimated solar wind c...

Liver regeneration from the facultative hepatic stem cells, the oval cells, takes place in situations in which liver regeneration from pre-existing hepatocytes is prevented. Different models have been used to stimulate oval cell response. Many of them involve the use of carcinogenic agents with or without partial hepatectomy. In this study we show that adenovirus-mediated gene transfer of the s...