Background: Epithelial ovarian cancer (EOC) is the deadliest malignancy among gynecologic tumors, and serous cystadenocarcinoma (OV) dominant histological type. Ferroptosis a novel iron-dependent, programmed form of cell death, agents that trigger ferroptosis may constitute potential anti-cancer therapies. Materials Methods: We herein extracted genes participate in process from online FerrDb da...

Specific binding of immunoliposomes to target tumor cells was investigated in a xenograft model (athymic nude mice) of i.p. growing human ovarian carcinoma (OVCAR-3). For the first time, quantitative evidence is presented that attachment of a tumor-specific antibody (OV-TL 3) dramatically enhances the association of liposomes with i.p. growing OVCAR-3 cells. The OV-TL 3-mediated binding of lipo...

A novel filarial serine protease inhibitor (SPI) from the human parasitic nematode Onchocerca volvulus, Ov-SPI-1, was identified through the analysis of a molting third-stage larvae expressed sequence tag dataset. Subsequent analysis of the expressed sequence tag datasets of O. volvulus and other filariae identified four other members of this family. These proteins are related to the low molecu...

PURPOSE Almost all patients with epithelial ovarian cancer receive chemotherapy and, concurrently, the synthetic steroid hormone dexamethasone to alleviate the side effects. This study aims to test the impact of steroid hormones on the apoptosis of epithelial ovarian cancer cells and to identify its mediators. EXPERIMENTAL DESIGN Tumor cell lines from 19 patients with advanced epithelial ovar...

INTRODUCTION Preliminary data suggested that non-invasive methods could be useful to assess presence of oesophageal varices (OV) in liver cirrhosis. The primary objectives were to investigate non-invasive markers for diagnosing and grading OV in patients with primary biliary cirrhosis. MATERIAL AND METHODS This study included a total of 106 consecutive treatment-naive patients with primary bi...

Circadian rhythms in mammals are regulated not only globally by the master clock in the suprachiasmatic nucleus (SCN), but also locally by widely distributed populations of clock cells in the brain and periphery that control tissue-specific rhythmic outputs. Here we show that the oval nucleus of the bed nucleus of the stria terminalis (BNST-OV) exhibits a robust circadian rhythm in expression o...

Background: Cancer antigen CA125 is known as a valuable marker for the management of ovarian cancer. Methods: The analytical and clinical performance of the Access OV Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA125 on the Elecsys System (Roche Diagnostics). Results: Total imprecision (%CV) of the ...

AIMS To analyse the distribution of OV-TL 3 and MOv18 in normal ovarian tissue to determine which antibody is most suitable for (radio)immunotherapy of ovarian carcinoma. METHODS The distribution of OV-TL 3 and MOv18 was determined using immunohistochemistry and flow cytometry. RESULTS Epithelial and other cells in many tissues, and leucocytes in peripheral blood, bone marrow and spleen sta...

Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism action two-fold: direct cell lysis and unmasking the cancer through immunogenic death, which allows immune system to recognize eradicate tumours. Breast most common in women challenging treat with immunotherapy modalities because it classically immunogenically “cold” tumour type. This provides attractive...