Autologous bone grafting remains the gold standard for bone grafting in clinical practice. Although it has withstood the test of time, it remains associated with multiple comorbidities. The search for an alternative bone graft substitute harnessing bone's osteoconductive, osteoinductive, and osteogenic properties remains a challenge. This article examines the various bone grafting materials cur...

Fracture healing is a complex process requiring mechanical stability, an osteoconductive matrix, and osteoinductive osteogenic biology. This intricate easily disrupted by various patient factors such as chronic disease lifestyle. As the medical complexity age of patients with fractures continue to increase, importance developing relevant experimental models becoming paramount in preclinical res...

Spinal fusion procedures remain a common therapeutic option for various pathologic conditions of the human spine. The most frequent method for inducing spinal fusion uses autologous bone grafts harvested from the iliac crest or from local bone removed during the spinal decompression. Although autologous bone remains the ¡§gold standard¡ ̈ for stimulating bone repair and regeneration, modern mole...

OBJECTIVE To review the role of mesenchymal stem cells (MSC) in bone formation and regeneration, and outline the development of strategies that use MSC in bone healing and regeneration. STUDY DESIGN Literature review. METHODS Medline review, synopses of authors' published research. RESULTS The MSC is the basic cellular unit of embryologic bone formation. Secondary bone healing mimics bone...

OBJECTIVE Synthetic calcium phosphate bone substitutes are widely used in sinus graft procedures due to their osteoconductive and biocompatible properties. Hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and HA/β-TCP composite are the most applied materials. The aim of this study was to propose a new mineralogical formulation, HA/tetracalcium phosphate (TTCP), as biomaterial for bone re...

Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A - doped castor bean polymer with bioactive glass; group B - castor bean polymer and; ...

Autologous bone graft has been used for a long time as the only material capable of osteogenesis, osteoinductive and osteoconductive in regeneration medicine. However, revolutionary discoveries have introduced a wide range of bone regeneration materials (BRMs) with improved characteristics, comparable to those of the gold standard (autograft). Thus, the determination of the product for optimal ...