The osmoregulatory pathways of the moderately halophilic bacterium Halomonas elongata DSM 3043 have been investigated. This strain grew optimally at 1.5 to 2 M NaCl in M63 glucose-defined medium. It required at least 0.5 M NaCl for growth, which is a higher concentration than that exhibited by the H. elongata type strain ATCC 33173. Externally provided betaine, choline, or choline-O-sulfate (bu...

Abstract Maize is one of the strategic food crops and has economic value could be developed because its position as main carbohydrate protein source after rice. This a reference for us to increase maize cultivation, seeing role quite large, availability less stable every year. can grow optimally on productive land marginal land, but at this time more used rice production. One alternative produc...

Therapeutics delivery into cells has been hurdled due to the barrier of cytoplasmic membrane. Although cell penetrating peptide (CPP) can potentially serve as an intracellular drug delivery vehicle, the application of CPP-based delivery is limited because the unsatisfactory delivery efficiency of CPP conjugated potent cargos is challenging their applications in present. Thus, the development of...

Bacteria are thought to cope with fluctuating environmental solute concentrations primarily by adjusting the osmolality of their cytoplasm. To obtain insights into the underlying metabolic adaptations, we analyzed the global metabolic response of Escherichia coli to sustained hyperosmotic stress using nontargeted mass spectrometry. We observed that 52% of 1,071 detected metabolites, including k...

Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we find that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival p...

Maize is a cereal crop which plays an important role in ensuring food security and social economic stability. It grown different environments. Global agriculture currently encountered with large scale alkalinity stress. Supplementing silicon, alternative way for overcoming the negative effects of sodicity on plant growth yield cheaper than other methods to reduce sodicity. Hence, pot experiment...

Background Dry Eye Disease (DED) is a multifactorial disease, with a high prevalence, that can have a great impact on the quality of life of patients. The first step of treatment includes the use of lacrimal substitutes composed of polymers, possible to associate osmoprotectant agents to the lacrimal substitutes. The aim of this article is to analyze the properties of the combination of hyaluro...

Indian mustard [Brassica juncea (L.) Czern & Coss] is one of the most important oilseed crops worldwide yet drought and salinity stress significantly reduced its growth yield. The research was carried out in order to test effect on osmoprotectants (total soluble sugars, proline), antioxidant molecules (ascorbate, ?-tocopherol) ionic content from dry sample leaves introgression lines varieti...