OBJECTIVE To measure oncostatin M (OSM) in synovial fluid from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS 20 samples of synovial fluid from patients with RA and 10 samples from patients with OA were examined using an OSM specific sandwich ELISA. RESULTS OSM was detected at concentrations ranging from 2.36 to 901.82 pg/ml in 18 (90%) of 20 samples of synovial fl...

Online Social Media (OSM) websites have attracted millions of users by enabling them to socially interact in ways that were not possible before. While the explosion of OSM use has had many benefits, it also has a darker side where an individual's personal information can potentially be misused. This study develops and tests an empirical model based on a theoretical lens provided by Protection M...

Growing evidence suggests that a proportion of interstitial myofibroblasts detected during renal tubulointerstitial fibrosis originates from tubular epithelial cells by a process called epithelial-mesenchymal transition (EMT). The IL-6-type cytokine oncostatin M (OSM) has been recently implicated in the induction of EMT. We investigated OSM effects on the expression of both cell-cell contact pr...

BACKGROUND/AIM Oncostatin M (OSM) and interleukin-6 (IL-6) are growth factors for prostate cancer (PC). Vascular endothelial growth factor (VEGF) and urokinase-type plasminogen-activator (u-PA) have been implicated in tumour progression. A possible interaction between IL-6, OSM, u-PA and VEGF in PC was investigated. MATERIALS AND METHODS Primary prostate epithelial cells (PPEC) and DU-145 PC ...

The interleukin-6 cytokine oncostatin M (OSM) induces potent growth-inhibitory and morphogenic responses in several different tumor cell types, highlighting the importance of OSM signaling mechanisms as targets for therapeutic intervention. The specific molecular pathways involved are not well understood, as OSM can signal through two separate heterodimeric receptor complexes, glycoprotein 130 ...

OpenStreetMap (OSM) is a recent emerging area in computational science. There are several unexplored issues in the quality assessment of OSM. Firstly, researchers are using various established assessment methods by comparing OSM with authoritative dataset. However, these methods are unsuitable to assess OSM data quality in the case of the non-availability of authoritative data. In such a scenar...

Neovascularization of the atherosclerotic plaque is responsible for its weakening and consequently for the complications of vascular disease. Macrophages are a source of growth factors that can modulate angiogenesis. In this study, we analyzed the effect of oncostatin M (OSM) on angiogenesis, as it could be involved in the development of atherosclerosis. The effect of OSM was compared with thos...

The effects of the production of two closely related cytokines, oncostatin M (OSM) and leukaemia inhibitory factor (LIF), by astrocytoma cells were investigated using the stable cell line human U373-MG, which expressed and secreted both biologically active polypeptides. The expression of LIF by these cells caused resistance to this cytokine due to loss of the LIF receptor (LIFR), from the cell ...

Oncostatin M (OSM) is a multifunctional member of the interleukin-6 cytokine family. OSM has been implicated as a powerful proinflammatory mediator and may represent a potentially important, novel therapeutic opportunity for treatment of established rheumatoid arthritis. To further investigate the role of OSM in inflammatory disorders, we have isolated a series of RNA aptamers that bind specifi...

An OpenStreetMap (OSM) landuse and landcover product (LULC) was published under osmlanduse.org. The product is based on the globally accessible OSM-data and the landuse classes orient themselves towards the legend of the Coordination of Information on the Environment (CORINE). Specific OSM tags are used to create classes in OSM LULC. The product is freely accessible and a first prototype for a ...