نتایج جستجو برای: orthoesters

تعداد نتایج: 89  

2015
René-Chris Brachvogel Frank Hampel Max von Delius

The discovery of coronands and cryptands, organic compounds that can accommodate metal ions in a preorganized two- or three-dimensional environment, was a milestone in supramolecular chemistry, leading to countless applications from organic synthesis to metallurgy and medicine. These compounds are typically prepared via multistep organic synthesis and one of their characteristic features is the...

2011
Paul A. Wender Nicole Buschmann Nathan B. Cardin Lisa R. Jones Cindy Kan Jung-Min Kee John A. Kowalski Kate E. Longcore

The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit a remarkable range of potent biological activities. Although partial activity information is available for some natural daphnanes, little information exists for non-natural congeners or on how changes in structure affect mode of action, function, potency or selectivity. A gateway str...

2012
Rainer Beckert Andreas Koschella Susann Dorn Thomas Heinze Adiaratou Togola Berit Smestad Paulsen

Non-naturally branched polysaccharides were prepared homogeneously by reaction of cellulose in N,N-dimethyl acetamide/LiCl and the ionic liquid 1-N-butyl-3-methylimidazolium chloride with 2,3,4,6-tetraacetyl-1-bromo-α-D-glucopyranoside in the presence of triethylamine as base. Degrees of substitution up to 0.58 were realized. The samples were soluble in dimethyl sulphoxide and water. NMR spectr...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Poncho L Meisenheimer H Tetsuo Uyeda Dongping Ma Mary Sobol Mark G McDougall Cesear Corona Dan Simpson Dieter H Klaubert James J Cali

Cytochrome P450 (P450) assays use probe substrates to interrogate the influence of new chemical entities toward P450 enzymes. We report the synthesis and study of a family of bioluminogenic luciferin acetal substrates that are oxidized by P450 enzymes to form luciferase substrates. The luciferin acetals were screened against a panel of purified P450 enzymes. In particular, one proluciferin acet...

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