Single-molecule experiments on immobilized molecules allow unique insights into the dynamics of molecular machines and enzymes as well as their interactions. The immobilization, however, can invoke perturbation to the activity of biomolecules causing incongruities between single molecule and ensemble measurements. Here we introduce the recently developed DNA origami as a platform to transfer en...

DNA origami represents a class of highly programmable macromolecules that can go through conformational changes in response to external signals. Here we show that a two-dimensional origami rectangle can be effectively folded into a short, cylindrical tube by connecting the two opposite edges through the hybridization of linker strands and that this process can be efficiently reversed via toehol...

DNA provides an ideal substrate for the engineering of versatile nanostructures due to its reliable Watson-Crick base pairing and well-characterized conformation. One of the most promising applications of DNA nanostructures arises from the site-directed spatial arrangement with nanometer precision of guest components such as proteins, metal nanoparticles, and small molecules. Two-dimensional DN...

A modern technique of designing origami has been established for several decades. This technique enables people to constitute a crease pattern by drawing lines (creases) on a sheet of paper based on mathematical theories, and to create realistic origami works. However, design of the crease patterns using this technique requires expertise. Furthermore, it is difficult to fold the origami model f...

origami or the art of paper folding is one of the traditions and hobbies that has been survived from ancient china. nowadays because of environmental issues and increase of attempts to reduce energy consumption, various and novel designs and also environmental friendly techniques in the origami art moves toward being scientific and popular in the packaging industry. in this article, in addition...

Origami, the art of paper sculpture, is a fresh challenge for the field of robotic manipulation, and provides a concrete example for many difficult and general manipulation problems. This paper describes our initial exploration, and highlights key problems in manipulation, modeling, and design of foldable structures. Results include the first origami-folding robot, a complete fold-sequence plan...

A key problem in nanotechnology is the precise assembly of nanoparticles on a substrate. DNA self-assembly using Watson-Crick base pairing, termed DNA Origami, is regarded as a promising route towards achieving nanoscale precision. We propose to address the problem of scaling up DNA Origami, by designing Origami structures whose mutual interaction is spatially non-uniform and results in directe...

We investigate the nonlinear wave dynamics of origami-based metamaterials composed of Tachi-Miura polyhedron (TMP) unit cells. These cells exhibit strain softening behavior under compression, which can be tuned by modifying their geometrical configurations or initial folded conditions. We assemble these TMP cells into a cluster of origami-based metamaterials, and we theoretically model and nume...

DNA origamis are fully tailored, programmable, biocompatible and readily functionalizable nanostructures that provide an excellent foundation for the development of sophisticated drug-delivery systems. However, the DNA origami objects suffer from certain drawbacks such as low cell-transfection rates and low stability. A great deal of studies on polymer-based transfection agents, mainly focusing...

A novel 3D microfluidic paper-based immunodevice, integrated with blood plasma separation from whole blood samples, automation of rinse steps, and multiplexed CL detections, was developed for the first time based on the principle of origami (denoted as origami-based device). This 3D origami-based device, comprised of one test pad surrounded by four folding tabs, could be patterned and fabricate...