Hen brain and spinal cord contain a number of esterases that hydrolyze phenyl valerate (PV). Most of this activity is sensitive to inhibition by micromolar concentrations of paraoxon. Included among the paraoxon-resistant esterases is neurotoxic esterase (NTE), which is inhibited in vivo and in vitro by certain organophosphorus compounds, such as mipafox, which cause delayed neurotoxicity. Sinc...

OBJECTIVE Adequate consumption of fruits and vegetables is a part of recommendations for a healthy diet. The aim of the present study was to assess acute cumulative dietary exposure to organophosphorus and carbamate pesticides via fruit and vegetable consumption by the population of schoolchildren aged 11-12 years and the level of risk for their health. DESIGN Cumulative probabilistic risk as...

Chlorpyrifos (CPS) is a widely used diethyl organophosphorus insecticide in agricultural settings. Household and urinary residue analysis has suggested that children in agricultural communities are at risk of exposure to diethyl organophosphorus insecticides. The effects of repeated postnatal exposure to CPS and its metabolite chlorpyrifos-oxon (CPO) on total muscarinic acetylcholine receptor (...

An efficient access to a novel series of organophosphorus compounds with cyclosulfamide moiety is described. Starting from α-hydroxyphosphonates, the 2-chloroethyl-(1, 2, 5- thiadiazoline-2-carbonyloxy-1- dioxide) phosphonates were prepared in three steps including an Abramov reaction, carbamoylation-sulfamoylation chlorosulfonyl isocyanate and intramolecular cyclisation. The spectroscopic meth...