The concept of senescence as a barrier to tumorigenesis, either by natural replicative limits or as stress-induced senescence deserves a critical evaluation of the benefits that can be achieved for cancer diagnosis and therapy. It is accepted that neoplastic cells can be forced to undergo senescence by genetic manipulations and by epigenetic factors, including anticancer drugs, radiation and di...

BACKGROUND Delayed and missed diagnoses lead to significant patient harm. Because physician actions are fundamental to the outpatient diagnostic process, a study was conducted to explore physician perspectives on diagnosis. METHODS As part of a quality improvement initiative, an integrated health system conducted six physician focus groups in 2004 and 2005. The focus groups included questions...

Meeting effectiveness depends on many factors. This paper explores one of them: the organizational integration of meeting outcomes. As we have observed, meeting outcomes do not flow easily to other organizational processes. Typically, the decisions taken in meetings are conveyed through meeting minutes, a situation that creates a gap of time, and sometimes a gap of interpretation, between meeti...

As organizations increasingly depend on information technology for their operation, complexity of information systems becomes an important issue for management in the context of organizational engineering. This paper shows how the combination of cybernetics with conceptual modelling contributes to the measurement of complexity for the analysis and design of information systems and organizations...

Today’s workflow systems are crossing organizational boundaries and usually involve multiple organizations or partners, and the crossorganization workflow has received much public attention from both the academia and the industry. This way the property analysis as well as system control for a cross-organization workflow is very important. In this paper, we focus on a kind of loosely coupled wor...

Background & Aims of the Study: Investigating and recognizing effective internal factors of organizations has always been one of the concerns in pursuit of organizational goals and to raise level of personnel’s safety, welfare and job performance. This study was aimed to evaluate psychometric characteristics of Organizational Diagnosis Questionnaire (ODQ) in small-scale industries in Hamedan pr...

Diagnostic interpretation at auscultation of heart murmurs is accompanied by frequent errors. It creates serious clinical, pedagogical, organizational and social problems. The standard nosological principle of a clinical information description from the diagnosis (a disease name) to the description of symptoms/signs contradicts to real clinical practice from revealing of symptoms through differ...