In a recent issue of the Journal, Taylor et al. (1) argued that selenium appears to play an important role not only in preventing various cancers but also in some degenerative diseases. Most of the data on the cancer prevention and cancer reduction effects of selenium are derived from epidemiologic studies (2). However, despite strong evidence for the importance of selenium in carcinogenesis, v...

Organic selenium compounds possess numerous biological properties, including antioxidant activity. Yet, the high toxicity of some of them, such as diphenyl diselenide (DPDS), is a limiting factor in their current usage. Accordingly, we tested four novel organic selenium compounds in the non-parasite nematode Caenorhabditis elegans and compared their efficacy to DPDS. The novel organic selenium ...

Vertical and horizontal profiles from the North and South Pacific Oceans demonstrate the existence of three species of dissolved selenium: selenite, selenate, and organic selenide (operationally defined). In surface waters, organic selenide makes up about 80% of the total dissolved selenium, selenite concentrations are uniformly low, and selenate concentrations rise with increased vertical mixi...

The use of sulfurand selenium-based linkers in polymer-supported organic synthesis (PSOS) is reviewed. The literature describing the application of sulfur-based linkers in the PSOS of small molecules and combinatorial library preparation from 2000 to the present is summarized. The development and use of selenium-based linkers in PSOS, highlighting the work of the Nicolaou and Huang groups, is a...

The experiment was conducted to study productive, physiological and immunological parameters in Bandarah local chicks as affected by dietary organic selenium (SelPlexTM). All chicks were used in the present work produced from females and males fed diets with 0.0, 0.1, 0.2 and 0.3 mg Se / kg diet in the form of selenium yeast (Sel-PlexTM). Two hundred unsexed oneday old chicks (50 chicks per par...

Selenium is generally known as an antioxidant due to its presence in selenoproteins as selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly concentration and chemical species dependent. One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. These redox active compounds are pro-oxidative and highly cytotoxic t...

Selenium is a naturally occurring substance that is toxic at high concentrations but is also a nutritionally essential element. Hydrogen selenide is the most acutely toxic selenium compound. Acute (short-term) exposure to elemental selenium, hydrogen selenide, and selenium dioxide by inhalation results primarily in respiratory effects, such as irritation of the mucous membranes, pulmonary edema...

Organoselenium compounds have been known for a long time as versatile reagents in organic chemistry. In the last years there has been a considerable development of selenium-based methods for organic synthesis. Many of these methods are currrently been used as standard procedures to introduce new functional groups under mild conditions. From the several areas of interest in organoselenium chemis...

Sustainable aquaculture, from both ecological and economic perspectives, demands a substantial reduction of the amount of fishmeal used in aqua feed. Instead, plant-derived protein feed stuff, which provide a nutritious diet offer a promising alternative for inclusion in aqua feed. In this study, the effects of organic selenium supplementation in low and high soybean meal-based practical diets ...

Sustainable aquaculture, from both ecological and economic perspectives, demands a substantial reduction of the amount of fishmeal used in aqua feed. Instead, plant-derived protein feed stuff, which provide a nutritious diet offer a promising alternative for inclusion in aqua feed. In this study, the effects of organic selenium supplementation in low and high soybean meal-based practical diets ...