Mouse models of human diseases are used to study the metabolic and physiological processes leading to altered whole-body energy expenditure (EE), which is the sum of EE of all body organs and tissues. Isotopic techniques, arterio-venous difference of substrates, oxygen, and blood flow measurements can provide essential information to quantify tissue/organ EE and substrate oxidation. To compleme...

IgG4-related disease (IgG4-RD) may involve multiple organs. Although it usually presents as diffuse organ involvement, localized mass-forming lesions have been occasionally encountered in pancreas. However, the same pattern has been seldom reported in biliary tract. A 61-year-old male showed a hilar bile duct mass with multiple enlarged lymph nodes in imaging studies and he underwent trisection...

To the Editor: The study by Grissom et al1 demonstrated a high correlation of the Modified Sequential Organ Failure Assessment (MSOFA) with the Sequential Organ Failure Assessment (SOFA) to predict mortality in patients with critical illnesses. The accompanying editorial by Rubinson et al2 cautioned readers not to rely solely on the SOFA or MSOFA score to prioritize patients during a mass criti...

A 58-year old male presented with a hard lump in lower abdomen extending into pelvis. Clinical examination and computed tomography scan revealed pelvic retroperitoneal mass. Patient underwent exploratory laparotomy - revealing a well encapsulated retroperitoneal mass extending up to coccyx, posterior to the urinary bladder. It had displaced the recto-sigmoid colon and urinary bladder to the rig...

solving the dilemma of the organ shortage in malaysia requires educating malaysians about organ donation and transplantation. this paper aims at exploring the average malaysian households ' preferred channels of campaigns and the preferred campaigners in a family setting, targeting at the dialysis family members.we analyzed the responses of 350 respondents regarding organ donation campaigns. th...

AasraAcr.-Embryonic oxygen consumption and organ growth were measured in the Laysan Albatross (Diomedea immutabilis). The logarithms of oxygen consumption and organ mass increased linearly with the logarithm of whole-embryo wet mass. The rate of growth of skeletal muscle and the gastro-intestinal tract exceeded that of the embryo as a whole, while the heart, lungs, brain, and eyes grew more slo...

The study of organ size control is a discipline of developmental biology that is largely unexplored. Although the size of an organ or organism depends largely on cell numbers and cell size, studies have found that the simple deregulation of cell proliferation or cell growth does not necessarily lead to changes in organ size. Recent genetic screens in Drosophila suggest that mutations that do af...

BACKGROUND Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear. OBJECTIVE We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM. DESIGN Forty-five o...

BACKGROUND We previously derived a whole-body resting energy expenditure (REE) prediction model by using organ and tissue mass measured by magnetic resonance imaging combined with assumed stable, specific resting metabolic rates of individual organs and tissues. Although the model predicted REE well in young persons, it overpredicted REE by approximately 11% in elderly adults. This overpredicti...