This study aimed to investigate tourniquet-induced compartment syndrome of the limb, consequential development multiple organ dysfunction syndrome, and its counteraction with pentadecapeptide BPC 157 therapy.

OBJECTIVE To identify the independent variables associated with death within 4 days after the first sepsis-induced organ dysfunction. METHODS In this prospective observational study, severe sepsis and septic shock patients were classified into 3 groups: Group 1, survivors; Group 2, late non-survivors; and Group 3, early non-survivors. Early death was defined as death occurring within 4 days a...

Multiple organ failure (MOF) is a common cause of death in intensive care unit (ICU) patients [1]. But what are the mechanisms underlying the development of MOF? Why, when we can support many of the individual organs, e.g., the kidneys with extracorporeal renal support, the lungs with mechanical ventilation, etc., do we all too often end up withholding/withdrawing these life-supporting therapie...

Immune suppression plays an important role in the pathogenesis of acute pancreatitis. Monocyte expression of HLA (human leucocyte antigen)-DR, a cellular marker of immune suppression, was determined in relation to the development of organ dysfunction in patients with acute pancreatitis. A total of 310 consecutive patients with acute pancreatitis, admitted to a university hospital within 72 h of...

INTRODUCTION When minimally invasive therapy was introduced, it became possible to cure some patients without open surgery, or at least delay the operation for longer than a month. AIM To determine the optimal timing to operate on patients with severe acute necrotizing pancreatitis based on the severity of organ insufficiency. MATERIAL AND METHODS A retrospective analysis was performed in a...

The syndrome of multiple organ failure has been recognised as a distinc t entity since the 1970s, and is the leading cause of mortality in intensive care1. It was subsequently appreciated that patients develop a spectrum of organ dysfunction which may or may not require pharmacological (eg inotropic) or mechanical (eg ventilation) support. This led to the coining of a new syndrome, multi-organ ...

Polycystic Ovarian Syndrome (PCOS) is endocrine and gynecological disorder that affects women of reproductive age. This a case report patient with PCOS who was misdiagnosed presented several symptoms. emphasizes the need for holistic healthcare approach to treat underlying organ dysfunction in PCOS. It highlights interconnectedness between dysfunction. examines chronic inflammatory state, risk ...