OBJECTIVES/HYPOTHESIS The incidence of occult perifacial nodal disease in oral cavity squamous cell carcinoma is not well reported. The purpose of this study was to evaluate the incidence of isolated perifacial lymph node metastasis in patients with oral squamous cell carcinoma with a clinically node-negative neck. The study will shed light on current controversies and will provide valuable cli...

Toll-like receptor 5 (TLR5) is an pattern recognition receptor expressed by several cells of the immune system that recognizes bacterial flagellin. We studied the influence of TLR5 in oral tongue squamous carcinoma and found that its expression levels predict patient survival and recurrence. Considering the role of microbiome in oral cancer, TLR5 may represent an important link between bacteria...

The underdiagnosis of extrapulmonary tuberculosis lesions, along with an emerging global resistance to antitubercular drugs, warrants an increased awareness of the involvement of Mycobacterium tuberculosis in atypical lesions of oral cavity. Tongue is the most common site of oral tuberculosis. We report a rare presentation of lingual tuberculosis in a 65-year-old male, a chronic tobacco chewer,...

Background. A case report of a nonhealing ulcer of the tongue histologically proven to be adenocarcinoma. Method. A 92-year-old man underwent clinical, immunochemistry, and imaging investigation. Results. Tests confirmed a distant metastasis of a primary colorectal carcinoma. Conclusion. Metastasis from colorectal carcinoma to the oral cavity is primarily to bone, but non-healing ulcers of the ...

objective: systemic sclerosis (ss) is a chronic autoimmune disease of connective tissue, which involves skin and internal organs, and results in collagen deposition and fibroblasts activation. studies have reported a higher risk of malignancy in patients with progressive systemic sclerosis (pss).the aim of this study is to report a case of tongue squamous cell carcinoma (scc) in a patient with ...

BACKGROUND Cervical nodal status is one of prognostic factors in head and neck squamous cell carcinoma (HNSCC). The objective of this study was to identify prognostic factors of cervical node status including site and size of primary tumors, presence of lymphovascular invasion, and size of cervical node for appropriate further treatment in HNSCC. METHODS A 5-year retrospective review of patie...

Introduction: Patients with thyroid carcinoma have increased risk for development of second malignancy either synchronous or metachronous. We are reporting a rare case of synchronous squamous cell carcinoma oral tongue and papillary thyroid carcinoma. Case Report: A 60-year-old smoker male was presented with the complaints of non-healing ulcer (2x2 cm) at right anterolateral tongue since six mo...

the aim of this study was to ascertain the prevalence of human papillomavirus (hpv) 16/18 in oral squamous cell carcinoma (oscc) and normal oral mucosa in iranian individuals with oscc and their association with various risk factors. the investigation followed a hospital-based case-control design. cases were individuals with diagnosed oscc, age- and sex-matched with controls. sixty-six paraffin...

Aim Distal metastases to oral cavity are very rare. Adenocarcinoma, renal cell carcinoma (RCC) and squamous cell carcinoma are the most common metastatic tumours. The aim of this study was to assess the diagnostic relevance of metastatic renal cell carcinoma on tongue manifestations in large patient series. Methods A patient with distal RCC metastases to the tongue and neck lymph nodes as the f...

OBJECTIVE To evaluate need of elective neck dissection in patients with early oral tongue cancer, and to see the pattern of involvement of different lymph node levels. METHODS Ninety four patients with T1-T2, N0 squamous cell carcinoma of the oral tongue were treated with a partial glossectomy and an elective modified radical neck dissection. RESULTS Thirty two patients had T1 and 62 patien...