BACKGROUND Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions. Respiratory failure, due to recurrent pulmonary infection and inflammation, is the most common cause of mortality. Muco-active therapies (e.g. dornase alfa and nebulized hypertonic saline) may decrease sputum viscosity, increase airway clearance of sputum, reduce infection and inflammatio...

Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening. Materials and Met...

Aim: Altered lipid profile patterns have been associated with pre-malignancies and malignancies because lipids play a vital role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in untreated patients with oral submucous fibrosis (OSF) and compared the changes in serum lipid profiles among various histological grades of OSF. Materials and metho...

Oral leukoplakia, oral submucous fibrosis and erythroplakia are 3 major types of oral premalignant lesions. Multiple oral premalignant lesions may possibly develop due to field cancerization, where carcinogenic exposures can cause simultaneous genetic defects to the upper aerodigestive tract epithelium, putting the epithelium at high risk for development of premalignant lesions at different sta...

Interstitial lung disease (ILD) is a serious side-effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment. Therefore, it is necessary to study underlying mechanisms for the development of pulmonary fibrosis induced by EGFR-TKI and potential approaches to attenuate it. Metformin is a well-established and widely prescribed oral hypoglycemic drug, and has gained...

The altered pharmacokinetic properties of, e.g., aminoglycosides in cystic fibrosis patients have to be considered when pulmonary exacerbations are treated. Since reported data on ciprofloxacin, a fluorinated quinolone, are conflicting, we compared intravenous and oral administration in cystic fibrosis patients when treating them for mild symptoms of pulmonary infection. All of the patients wer...

Oral submucous fibrosis (OSMF), which presents with a severe degree of trismus, is a great surgical challenge. The surgical procedures include excision of fibrous bands with or without coverage of the surgically created defect. The use of vascularised flaps such as the palatal pedicled flap, tongue flaps, use of buccal fat pad and nasolabial flaps are becoming increasingly popular. We present a...

Background and PurPose: The three most common causes of trismus are oral submucous fibrosis, orofacial gangrene in malnourished children and cancers of the head and neck. 2 Very often, they share the same triad: fibrosis of the soft tissue of the cheek, masticatory muscles and osseous overgrowth. In severe cases, this will eventually lead to severe pain, weight loss and poor oral hygiene. 4, 5

Oral submucous fibrosis (OSMF) is characterized by excessive deposition of collagen in the connective tissue leading to secondary changes in epithelium. It has multifactorial etiology. This case reports Oral Submucous Fibrosis occurring in a 28 year old male with a history of betel quid chewing. Various treatment modalities are proposed such as nutritional support, immunomodulatory drugs, physi...

Free radical induced lipid peroxidation has been implicated in pathogenesis of several pathological disorders. Lipid peroxidation products malonaldehyde (MDA) was analyzed in 25 patients of leukoplakia, 47 patients of oral submucous fibrosis, 21 patients of candidiasis, 67 patients of dental caries, 62 patients of oral cancer and 50 patients of healthy subject served as a control. Significantly...