in the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. acute corneal pain was induced by the local application of hypertonic saline (5 m nacl) on the corneal surface, and the number of eye wipes was then counted for 30 s. subcutaneous (s...

introduction: neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. the role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. the aim of this study was to investigate the effect of alcoholic extract of onion on dia...

objective: the present study aimed to compare the value of ibuprofen and fennel for postpartum pain relief in women with normal vaginal delivery. materials and methods: in this randomized clinical trial we studied 90 women referring to obstetrics ward for normal vaginal delivery (nvd) in assali hospital in khoramabad. women were randomly allocated to receive either oral ibuprofen or oral fennel...

objective: the study evaluated the efficacy of oral calcium carbonate supplement on leg pain in pregnancy and nursing period. materials and methods: a total number of 176 women at third trimester of pregnancy or nursing period till to one year after delivery with complaint of leg pain, low back pain (lbp), and posterior pelvic pain (ppp) were evaluated for distinct primary causes and were exclu...

Oral ketorolac tromethamine (KT) in 10 and 20mg postoperative doses in an oral surgery pain model have proven to be equally analgesic as 400mg ibuprofen, and significantly better than acetaminophen and acetaminophen-codeine combinations. It prevents pain by blocking arachidonic-acid pathway. To evaluate the analgesic effect of preoperative KT-10mg, on pain during and after open flap debridement...

Patients with advanced gastrointestinal and pelvic malignancies commonly present with pain of varying severity. In a majority of these patients, pain can be effectively managed using an integrated systemic pharmacological approach with oral morphine being the cornerstone of treatment. However, with escalating doses, intolerable side effects of oral morphine may lead to patient dissatisfaction. ...

BACKGROUND Movement alterations are often reported in individuals with back pain. However the mechanisms behind these movement alterations are not well understood. A commonly cited mechanism is pain. The aim of this study was to investigate the effect of pain reduction, from oral analgesia, on lumbar kinematics in individuals with acute and chronic low back pain. METHODS A prospective, cross-...

A subanesthetic dose of oral ketamine proved able to reduce chronic pain. These findings support the idea that norketamine, a metabolite of ketamine, may have played an important part in the analgesia observed in these chronic-pain patients,4 although we did not measure the plasma concentration of norketamine. We did not observe serious adverse events or tolerance to oral ketamine in the presen...

Oral cancer pain is more severe, on average, than pain from any other cancer. The public health problem of cancer pain is, ironically, exacerbated by improved chemoand radio-therapies that prolong survival. The intensity of oral cancer pain escalates with disease progression; terminal patients generally experience debilitating pain during their final months of life. The etiology of oral cancer ...