Oral mucositis is a common morbidity induced by radiation therapy and chemo-radiotherapy for head and neck malignancies. This often results in treatment delays, premature treatment cessation and increased cost. New treatments of oral mucositis are emerging but effective remedies remain limited. Between February 2007 and May 2008, 21 patients with head and neck malignancies were treated with a s...

Oral mucositis is one of the most common side effects of cancer treatment (chemotherapy and/or radiotherapy). It is an inflammatory process that affects the mucosa of the oral cavity, giving rise to erythematous areas in combination with ulcers that can reach a large size. The true importance of oral mucositis is the complications it causes - fundamentally intense pain associated to the oral ul...

Introduction & Objectives More and more evidence is emerging that microbiota are involved in the development and severity of oral mucositis, an inflammation and ulceration of the mucosa after chemotherapy. It is known that the microbiome is changed during mucositis and that chemotherapy is often complicated with local and even systemic infections. But still little is known about the role of ora...

Head and neck cancer represents one of the main oncological problems. Its treatment, radiotherapy and chemotherapy leads to mucositis, and other side effects. The authors reviewed high-quality evidence published over the last 25 years on the treatment of cancer treatment-induced oral mucositis. A Medline search for double blind randomized controlled clinical trials between 1985 and 2010 was car...

Background: Treatment of cancer is increasingly effective, but associated with short and long term side effects, including oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy. Objective; To evaluate the clinical efficacy and safety of Methyl sulfonyl methane and N-acetyl cysteine in cancer chemotherapy and irradiation induced oral mucositis Mater...

BACKGROUND Oral mucositis is one of the most common side-effects of 5-fluorouracil (5-FU)-based chemotherapy. The objective of this study was to evaluate the effects of irsogladine maleate (IM) on fluorouracil-induced oral mucositis through a double-blind, placebo controlled trial. PATIENTS AND METHODS Patients (N = 66) were randomly assigned to receive either placebo or IM (4 mg/day for 14 c...

Background: Mucositis is a complex inflammatory response of the digestive system mucous membrane and it is also one of the most common painful side effects following chemotherapy in children with carcinoma. Developing to mucositis affects the patient's life severely and can lead to long – term hospitalization.Therefore, this study was conducted to evaluate the effect of chamomile mouthwas...

Oral mucositis remains one of the most dominant, serious, disrupThe mucositis puzzle is complicated and consists of multiple pieces tive, and symptomatic complications of radiation therapy used for the treatment of cancers of the head and neck (Villa and Sonis, 2015). Progressive mucosal injury accompanies increasing daily radiation fractions until confluent, deep, ulceration develops in the ma...

Oral radiation mucositis is one of the debilitating and dose-limiting acute toxicity during (chemo) radiation or for HNC having a major impact on the patient daily functioning, well-being and quality of life. The unplanned interruption of treatment secondary to mucositis may compromise the treatment and the outcomes if not adequately addressed. Recently, the integrated pathophysiological mechan...

Background and objectives: Oral mucositis is a common and debilitating complication of radiotherapy which is associated with significant morbidity. It is therefore extremely important that mucositis be prevented, or at least treated to reduce its severity and sequelae. The objective of the study was to manage oral mucositis induced by radiotherapy and to reduce pain by using Benzydamine hydroch...