The aim of this study was to develop an ionic liquid (IL) system for the enzymatic resolution of racemic ibuprofen ethyl ester to produce (S)-ibuprofen. Nineteen ILs were selected for use in buffer systems to investigate the effects of ILs as cosolvents for the production of (S)-ibuprofen using thermostable esterase (EST10) from Thermotoga maritima. Analysis of the catalytic efficiency and conf...

BACKGROUND The arterial ductus is a major communicative pathway which is naturally patent in the fetus, connecting the body of the major pulmonary artery to the descending aorta. Although usually closing on its own, the patent ductus arteriosus (PDA) may remain open in the second postnatal week due to a lack of prompt diagnosis in the initial days of life or an absence of prompt treatment. OB...

Calotropis gigantea Linn and Tridax procumbens Linn, are well documented medicinal plants distributed in Asia and Africa and are useful for many ailments. The anti-inflammatory activity of low dose of the aqueous extract of T. procumbens and ethanolic extract of C.gigantea were assessed on carrageenan induced paw edema and compared with standard drug Ibuprofen. The oral administration of 400mg/...

The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at normal gravity (1G) in humans. Six healthy human volunteers were given 600 mg oral dose ibuprofen during 1-day simulated µG antiorthostatic bed rest position, then at normal position (1G) in a sequential design with 7 days washout time. Saliva and plasma samples were obtained up to 8 hou...

BACKGROUND Ibuprofen is known to be efficacious in the treatment of tension-type headache, the most common form of primary headache. A novel tablet formulation of ibuprofen sodium is more rapidly absorbed than standard ibuprofen. This study evaluated onset of analgesia and overall efficacy of ibuprofen sodium in episodic-type tension headache (ETTH) compared with standard ibuprofen and placebo....

The NSAIDs have become increasingly popular for the perioperative period because of their opioid-sparing effects and potential for reducing opioid-related side effects and improving the recovery process (4). Unfortunately, nonselective NSAIDs such as ketorolac and ibuprofen also have the ability to interfere with platelet function, as well as the potential for producing adverse effects on gastr...

BACKGROUND Oral antipyretics are commonly used to treat pediatric patients who develop fevers. However, patients presenting to the emergency department or undergoing surgery are frequently unable to tolerate oral antipyretics. Rectal formulations are available; however, this route of administration is unpredictable. The main objectives of this randomized controlled study was to evaluate the eff...

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

Objective To evaluate efficacy and safety of rectal form of ibuprofen and comparing to indomethacin for treatment of patent ductus arteriosus (PDA) in premature neonates. Methods Single-center, cohort, prospective study without prerandomization was performed in 38 preterm infants at gestational age 25-31 weeks were treated in NICU of Dnepropetrovsk Regional Children's Hospital (Ukraine) during ...