OBJECTIVES This study aimed to investigate the effect of oral antiviral treatment on the prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radiofrequency (RF) ablation. METHODS Between January 2003 and December 2010, 228 patients without a history of antiviral treatment were treated with RF ablation for a single HBV-related HCC. We divided the patients into two...

the cancer of oral cavity is related to lesions of mucous membrane of tongue and gum that can be treated with radiation therapy. a lateral photon field can be used to treat this kind of tumor, which has a side‑effect on normal tissue in the opposite side of the oral cavity. in this study the dosimetric effect of the various shields in oral cavity is evaluated. in this study, a special phantom s...

In recent years, substantial progress has been made in the prevention and control of hepatitis B, a major cause of chronic liver disease, cirrhosis, and liver cancer worldwide. A safe and eff ective hepatitis B virus vaccine was developed in the early 1980s, and its subsequent widespread use resulted in notable decreases in rates of hepatitis B, at least in countries that adopted universal hepa...

800x600 hepatitis b virus (hbv) infection is the main cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc). several factors such as serum hbv dna level, genotype and specific viral mutations have been clarified to determine disease progression of chronic hepatitis b. among these, mutations can also occur in chronic hbv patients with antiviral treatment such as lamivudine the...

It is estimated that one-third of the world's population has been exposed to hepatitis B virus and that 300-400 million people have chronic hepatitis B. In areas of the world where hepatitis B infection is endemic, this chronic viral infection is a major cause of premature morbidity and mortality related to hepatocellular carcinoma (HCC) and complications of end-stage liver disease. Recent data...

Vaccines are the cornerstone of influenza control policy, but can suffer from several drawbacks. Seasonal influenza vaccines are prone to production problems and low efficacies, while pandemic vaccines are unlikely to be available in time to slow a rapidly spreading global outbreak. Antiviral therapy was found to be beneficial during the influenza A(H1N1)pdm09 pandemic even with limited use; ho...

OBJECTIVE To calculate the expected prevalence of resistant HIV mutants before antiviral therapy. DESIGN HIV replication generates virus mutants. The prevalence of these mutants is determined by mutation and selection/fitness. Some mutations will confer drug resistance and it is crucial for the success of antiviral drug therapy to determine whether these resistant viruses are present before t...

Long-term therapy with oral nucleoside/nucleotide analogues (NAs) is a favoured approach to the treatment of patients with chronic hepatitis B (CHB); however, all oral agents currently approved for the treatment of such patients are associated with some risk for drug resistance. This can lead to a rebound in HBV levels and, eventually, progressive liver disease. Combination therapy is one strat...

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-...

The hepatitis C virus (HCV) is common among people who inject drugs (PWID) and causes significant morbidity and mortality. Opiate replacement therapy and needle exchange programs have effectively prevented the transmission of the Human immunodeficiency virus (HIV) but have been less effective for HCV. Other HCV prevention strategies are needed. Antiviral therapy with all oral direct acting anti...