Connexin 36 (Cx36) is a channel-forming protein found in the membranes of apposed cells, forming the hexameric hemichannels of intercellular gap junction channels. It localizes to certain neurons in various regions of the brain including the retina. We characterized the expression pattern of neuronal Cx36 in the guinea pig retina by immunocytochemistry using specific antisera against Cx36 and g...

PURPOSE The effect of increased numbers of S-cone photoreceptors in enhanced S-cone syndrome (ESCS) was investigated psychophysically in six ESCS observers to understand more about relative cone sensitivities and postreceptoral organization. METHODS Measures of temporal sensitivity or delay were made: S- and L-cone temporal acuity (critical flicker fusion, or CFF), S-cone temporal contrast se...

The produced electric and magnetic fields due to lightning strikes to mountainous ground are determined in this paper. For the sake of simplicity a cone-shaped ground with finite conductivity is assumed to represent a natural nonflat ground. By this assumption, we deal with an axillary symmetrical structure so we use the cylindrical 2D-FDTD to save the simulation memory and time, dramatically. ...

In this paper, we introduce a cone generalized semi-cyclicφ−contraction maps and prove best proximity points theorems for such mapsin cone metric spaces. Also, we study existence and convergence results ofbest proximity points of such maps in normal cone metric spaces. Our resultsgeneralize some results on the topic.

We investigated how transient changes of background color influence the L- and M- (long- and middle-wavelength-sensitive-) cone signals in the luminance pathway. Motion identification thresholds were measured for a drifting sinusoidal grating (1 cycle/deg) modulated along different vector directions in L- and M-cone contrast space. The color of a central 4-deg-diameter region was briefly altere...

abstract background: we aimed to describe morphological and morphometrical characteristics of fasciola spp. in livestock from ardabil province, northwest iran. methods: forty adult flukes were collected from different definitive hosts (cattle and sheep). previously specimens were identified as f. hepatica or f. gigantica based on pcr-rflp of the its-1 region with rsai enzyme.  we identified fas...

The shutoff mechanisms of the rod visual transduction cascade involve G-protein-coupled receptor (GPCR) kinase 1 (GRK1) phosphorylation of light-activated rhodopsin (R*) followed by rod arrestin binding. Deactivation of the cone phototransduction cascade in the mammalian retina is delineated poorly. In this study we sought to explore the potential mechanisms underlying the quenching of the phot...

Purpose The apoptotic mechanisms responsible for secondary cone death in retinitis pigmentosa (RP) remain largely unknown. The cone-enriched apoptotic protease caspase-7 (Casp7) is thought to be triggered by endoplasmic reticulum (ER) stress and plays a pivotal role in mice deficient in the cone cyclic nucleotide-gated channels, a deficiency that causes achromatopsia in humans and in mice with ...