BACKGROUND About 10 million children worldwide live or work on the street. International reports estimate the prevalence of substance use among street children to be between 25% - 90%, which is who were referredntal disorders and high-risk behaviors. OBJECTIVES The objective of this study was to report the outcomes of assisted withdrawal of opioid-dependent vulnerable children and adolescents...

Background: Poisoning comprises about 7% of accidents in children under 5-year-old and 2% all pediatric deaths developing countries. To warn against prevent future potential poisoning with opioid substances, this comparative study was conducted on cases referred to the 17th Shahrivar Hospital Rasht, Iran, 2006 2018. Methods: In retrospective, cross-sectional study, hospitalized diagnosed 2018 w...

Background: Poisoning comprises about 7% of accidents in children under 5-year-old and 2% of all pediatric deaths in developing countries. To warn against and prevent future potential poisoning with opioid substances, this comparative study was conducted on pediatric cases referred to the 17th Shahrivar Hospital in Rasht, Iran, in 2006 and 2018. Methods: In this retrospective, cross-sectional ...

Background: The prevalence of opium addiction among Iranians is considerable. Since endogenous opioid systems may be altered as a consequence of addiction, it is very important to determine the plasma and cerebrospinal fluid (CSF) levels of morphine in Iranian patients addicted to opiates who will undergo surgery.Methods: We obtained CSF and plasma samples from 50 volunteers with an established...

Opium alkaloids counterparts are secreted by human and animal organisms but the role of endogenous opioid peptides in horses has not yet been fully elucidated. Endogenous opioids are involved in regulating food intake, sexual and social activity, pain relief and pain threshold regulation in horses as well as in regulating the functions of the immune system. The aim of this review is to describe...

Opioids are the primary drugs used in Western medicine for pain management and palliative care. Farming of opium poppies remains the sole source of these essential medicines, despite diverse market demands and uncertainty in crop yields due to weather, climate change, and pests. We engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work w...

Background: Opium is a new source of lead and considered as a cause of lead poisoning. As anemia and lead poisoning affect growth and behavior negatively, their timely prevention, diagnosis, and treatment are essential. The aim of thi study is evaluation of the prevalence of anemia, iron deficiency anemia, and lead poisoning in children with opioid toxicity. Materials and Methods: In this cr...

The perpetual pursuit of pain elimination has been constant throughout human history and pervades human cultures. In some ways it is as old as medicine itself. Cultures throughout history have practiced the art of pain management through remedies such as oral ingestion of herbs or techniques believed to have special properties. In fact, even Hippocrates wrote about the practice of trepanation, ...

Opiates such as morphine and codeine are mainly obtained by extraction from opium poppies. Fermentative opiate production in microbes has also been investigated, and complete biosynthesis of opiates from a simple carbon source has recently been accomplished in yeast. Here we demonstrate that Escherichia coli serves as an efficient, robust and flexible platform for total opiate synthesis. Thebai...

introduction in spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (nbs) is undetermined. we aimed to estimate the prevalence of nbs and other opioid bowel dysfunction (obd) in opioid abusers in kerman, southeast iran. according to the best of our knowledge, this is the first study to assess the prevalence of nbs in opioid abusers. method by ref...