Background: Osteonecrosis of the femoral head (ONFH) is an ischemic disease characterized by impairment angiogenesis. We have previously elucidated role tsRNAs and BMSC exosomes in ONFH, but whether tsRNA-modified promote angiogenesis ONFH remains unclear. Methods: The expression angiogenesis-related tsRNA plasma from patients was examined q-PCR. function HUVECs identified CCK-8 assay. Exosomes...

The hip joint is one of the major structures in the human body and the resultant force acting through the hip joint is 300% of body weight. Therefore, weight bearing, as a cause of ischaemia, may contribute to the development of non-traumatic osteonecrosis of the femoral head (ONFH). However, it remains unclear whether weight bearing is related to the development of non-traumatic ONFH. Therefor...

The imbalance between adipogenic and osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs) plays a significant role in the pathogenesis of steroid-induced osteonecrosis of the femoral head (ONFH). Several microRNAs (miRNAs) are involved in regulating adipogenesis and osteogenesis. In this study, we established a steroid-induced ONFH rat model to identify the potential relevan...

The polymorphism of the vascular endothelial growth factor (VEGF) -634C/G has been correlated with susceptibility to osteonecrosis of the femoral head (ONFH). The aim of this study was to derive a more precise estimation of the relationship between the VEGF -634C/G polymorphism and ONFH by performing a meta-analysis. We searched articles indexed in Pubmed, OVID and Web of Science published up t...

OBJECTIVE To investigate the prevalence of clinical anxiety and clinical depression in Chinese young and mid-aged patients with osteonecrosis of the femoral head (ONFH) and to analyze their potential risk factors. METHODS Two hundred and sixteen Chinese patients with ONFH were consecutively enrolled in this cross-sectional study from January 2010 to December 2010. The Zung self-rating anxiety...

We investigated the associations between vascular endothelial growth factors (VEGF), endothelial nitric oxide synthase (eNOS), and ATP-binding cassette subfamily B member 1 transporter (ABCB1) polymorphisms and the risk of osteonecrosis of the femoral head (ONFH). Published studies were reviewed and analyzed based on predefined selection criteria. The strength of the association between VEGF, e...

Genome-wide association studies have identified that the gene variants in Wnt signaling associate with bone mineral density and fracture risk but the effects of the variants on the development of osteonecrosis of the femoral head (ONFH) have been unclear. Here, we analyzed the polymorphisms of 4 variants in GSK3β and SFRP4 genes of Wnt signaling and their association with the development of ONF...

The results of total hip arthroplasty (THA) for osteonecrosis of the femoral head (ONFH) in elderly patients (80 years or older) has not been well defined. The purpose of this retrospective study was to evaluate the clinical course of and the results in noncemented THA for ONFH in elderly patients.Between 1998 and 2007, one hundred seven consecutive hips with ONFH in 103 patients were evaluated...

<p class="abstract"><strong>Background:</strong> Osteonecrosis of femoral head (ONFH) is characterised by cell death in the subchondral bone caused abnormalities blood flow to head. About 5% 13% arthroplasties are performed yearly for ONFH United States. Ficat and Arlet classification commonest system used grading ONFH. Advanced stages 3 4 best managed with total hip arthropla...

BACKGROUND Osteonecrosis of the femoral head (ONFH) is a progressive disease, which mainly affects young adults and often necessitates total hip arthroplasty (THA), so early interventions are critical to successfully protect hip joint from THA. In this review, our purpose was to determine the effects of anticoagulants for preventing and treating the primary and secondary ONFH, respectively, bef...