Although antitumor activity and a low toxicity profile have been demonstrated for several oncolytic viruses, the development of viral therapy in cancer treatment has been limited by a lack of definitive phase III trials. The use of replicating viruses to potentiate the efficacy of standard cancer therapies also awaits conclusive clinical testing. Based on preliminary results with new generation...

Department of Defense Breast Cancer Research Program Meeting, 2005. Sensitivity of Breast Tumors to Oncolytic Viruses. Seminar: Breast Cancer Center of Excellence, Wake Forest University Health Sciences, 2006. Treatment of Breast Cancer with Oncolytic VSV.

Clinical trials have confirmed the safety of selectively oncolytic adenoviruses for treatment of advanced cancers. However, increasingly effective viruses could result in more toxicity and therefore it would be useful if replication could be abrogated if necessary. We analyzed viruses containing the cyclooxygenase-2 (Cox-2) or vascular endothelial growth factor (VEGF) promoter for controlling r...

Selective replication of oncolytic viruses in tumor cells provides a promising approach for the treatment of human cancers. One of the limitations observed with oncolytic viruses currently used in the treatment of solid tumors is the inefficient spread of virus throughout the tumor mass following intratumoral injection. Data are presented showing that oncolytic adenoviruses expressing the relax...

Selective replication of oncolytic viruses in tumor cells provides a promising approach for the treatment of human cancers. One of the limitations observed with oncolytic viruses currently used in the treatment of solid tumors is the inefficient spread of virus throughout the tumor mass following intratumoral injection. Data are presented showing that oncolytic adenoviruses expressing the relax...

Purpose:Radiotherapy is part of the standardof care inhigh-grade gliomasbut its outcomes remainpoor. Integrating oncolytic viruses with standard anticancer therapies is an area of active investigation. The aim of this study was to determine how tumor-targeted ionizing radiation (IR) could be combined with systemically delivered oncolytic vaccinia virus. Experimental Design:U-87 glioma xenograft...

PURPOSE Radiotherapy is part of the standard of care in high-grade gliomas but its outcomes remain poor. Integrating oncolytic viruses with standard anticancer therapies is an area of active investigation. The aim of this study was to determine how tumor-targeted ionizing radiation (IR) could be combined with systemically delivered oncolytic vaccinia virus. EXPERIMENTAL DESIGN U-87 glioma xen...

Abstract: Background  and  Aims:  Huh-7  is  a  cell  line  that  was  derived  from  a  liver  tumor  of  a  Japanese  man.  Hepatocellular  carcinoma  (HCC)  is  considered  as  a  primary  liver  cancer.  Highly  resistant  tumor  to  treatment  which  causes  the  death  of  many  patients  annually.  Thus,  targeting  the  cancer  cells  by  using  a  new  method  could  be  effective  in...

Oncolytic virotherapy is the use of viruses to target a tumor for infection and lysis while leaving healthy cells uninfected. The history of viral oncology dates back to the turn of the 20th century when clinicians observed spontaneous regression of tumors after vaccination with attenuated viruses [1]. Experiments were done in the 1950s using Picornaviruses but soon fell out of favour to chemot...