Bioinspired (or biologically inspired) drug delivery systems (DDSs) have been intensively studied in the last decades. As bioinspired DDSs, membrane vesicles, including extracellular vesicles (EVs) released from eukaryotic cells, outer (OMVs) bacteria, cell-bound (CBMVs) isolated situ cell surfaces, reorganized after isolation of plasma and others rapidly developed are attracting more attention...

A reduction reaction of 5-hydroxymethylfurfural to 2,5-dimethylfuran (2,5-DMF) has been previously performed in an organic solvent under high-temperature conditions. For the relaxation such conditions, conventional palladium on carbon (Pd/C) was combined with vesicles composed phospholipids or surfactants. Pd/C 1,2-dioleoyl-sn-glycero-3-phosphocholine indicated a yield (25%) at 60 °C compared (...

In this paper, we study the interaction of charged polymers with solid-supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) membranes by in-situ neutron reflectivity. We observe an enormous swelling of the oligolamellar lipid bilayer stacks after incubation in solutions of poly(allylamine hydrochloride) (PAH) in D₂O. The positively charged polyelectrolyte molecules interact with the lip...

Extracellular Vesicles In article number 2211664, Yuehua Liu, Lin Yu, Liming and co-workers, design a hypoxic treatment strategy to increase extracellular vesicles (EVs) production boost their therapeutic efficacy. An injectable bioactive hydrogel is developed improve the in vivo stability retention of EVs, thereby synergistically accelerating bone regeneration. This simple but effective expect...

Six species of Sargassum C. Agardh (Sargassaceae) with compressed primary branches, including: S. binderi Sonder, S. aquifolium (Turner)C. Agardh, S. oligocystum Montagne, S. swartzii (Turner)C. Agardh, S. crassifolium J. Agardh and S. cristaefolium C. A. Agardh, were identified in the Persian Gulf and Oman Sea coasts, among which S. binderi is reported as newly recorded species in Iran for the...

Background: Hypothalamus-derived kisspeptins are critical regulators of reproduction in nearly all mammalian species including the humans. These small peptides mediate their actions through the GnRH loop system. How kisspeptins regulate gonadal maturation in sexually immature male mammals remains elusive. To address this, kisspeptin was administered as subchronic (12 days) twice daily i. p. dos...

Niosomes, non-ionic surfactant vesicles (NSVs), are the hydrated lipids composed mainly of different classes of non-ionic surfactants, introduced in the seventies as a cosmetic vehicle. Nowadays, niosomes are used as important new drug delivery systems by many research groups and also they are effective immunoadjuvants which some commercial forms are available in the market. These vesicles rece...

Mol. Nutr. Food Res. 2023, 67, 2200884 DOI: 10.1002/mnfr.202200884 Extracellular Vesicles (EVs) secreted from probiotics are potential EV-based nanomaterials therapy in inflammatory bowel disease (IBD). Clostridium butyricum-derived extracellular vesicles could be a novel agent for treating colitis and colonic miR-199a-3p might serve as therapeutic target IBD. This is reported by Yingping Xiao ...

Abstract During embryogenesis, optic vesicles, the eye primordium, develop from diencephalon via a controlled multistep process of organogenesis that has been difficult to reconstruct in humans. Using iPSC-derived human brain organoids, we demystify complexities and demonstrate organoids can innately forebrain-associated bilaterally symmetric vesicles. These next-generation with relevant cell d...