A patient accidentally received approximately 3 g of ofloxacin intravenously. She experienced only moderately severe central nervous system symptoms, which resolved within 9 h. The peak serum ofloxacin level was 39.3 micrograms/ml, approximately seven times the usual peak level. Ofloxacin may possess a considerable safety margin in humans.

For the simultaneous determination of Nitazoxanide and Ofloxacin in tablet dosage form, a simple reverse phase liquid chromatographic method was developed validated. A mobile containing acetonitrile, methanol, 0.4 M citric acid (60:30:10, v/v/v) used for separation. Thermo C18 (4.6mm*250 mm, 5 ) column used, with flow rate 1 mL/min UV detection at 300 nm. ofloxacin had retention times 3.071 12....

Background: Pathogenic micro-organisms are the most commonly involved etiologic agents in causing external ocular diseases. Conjunctiva, lid and cornea are the most commonly affected parts of the eye. Ofloxacin is exceptionally potent against a wide range of Gram-positive and Gram-negative bacteria and obligate anaerobes. It is also reported to be effective against ocular pathogens. The action ...

Aims—To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. Methods—31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were anal...

Background Ofloxacin is a second-generation fluoroquinolone that frequently has been prescribed against various bacterial infections. Serious hypersensitivity reactions will increase with high worldwide consumption. There have been few case reports of ofloxacin induced anaphylaxis and its pathogenic mechanism is not well understood. In this study, we investigated pathogenic mechanisms in a 20-y...

carvedilol is administered as a racemic mixture of the r(+)- and s(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. the aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. stereoselective interact...

The mechanism of action of the quinolone analogs ofloxacin and S-25930, which are unusual because of the presence of a third ring with an asymmetric carbon, was studied. Drug-resistant strains of Escherichia coli were selected by serial passage in the presence of ofloxacin, and a mutation was mapped near the gyrA gene of DNA gyrase. DNA gyrase containing the A subunit purified from this strain ...

A novel, rapid and sensitive analytical method is described for determination of ofloxacin and levofloxacin by enhanced chemiluminescence (CL) with flow-injection sampling. The method is based on the CL reaction of the Ce(IV)-Na2S2O4-ofloxacin/levofloxacin-H2SO2 system. The enhanced CL mechanism was developed and the optimum conditions for CL emission were investigated. The CL intensity was cor...

AIMS To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. METHODS 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were an...

Ofloxacin is a commonly used quinolone antibiotic both in adults as well as children. It is generally safe and well tolerated. Rarely, neurological and psychiatric adverse reactions are reported to occur with ofloxacin. We report a case of a child who developed delirium after ofloxacin treatment, that resolved after medication discontinuation and treatment with low dose olanzapine.