BACKGROUND No authors have investigated whether the administration of local oestrogens in addition to antimuscarinics could have a synergistic effect in the therapy of overactive bladder (OAB). OBJECTIVES To compare the efficacy of antimuscarinics alone versus antimuscarinics in combination with local oestrogens for OAB; to verify whether risk factors for lower antimuscarinic efficacy can be ...

Oestrogens influence the pathology and development of hormone-sensitive breast cancers. Tissue factor pathway inhibitor (TFPI) has been shown to be associated with breast cancer pathogenesis. Recently, we found TFPI mRNA levels to be significantly reduced by oestrogens in a breast cancer cell line (MCF7), a process mediated through the oestrogen receptor alpha (ERα). The aim of the present stud...

'Steroid hormones are essential for the growth, differentiation and function of many tissues in both animaIs and humans. It has been established by animal experimentation that modification of the hormonal environment by surgical removal of endocrine glands, by pregnancy or by exogenous administration of steroids can increase or decrease the spontaneous occurrence of tumours or the induction of ...

Oestrogen loss at the menopause has a profound influence on skin. Oestrogen treatment in post-menopausal women has repeatedly been shown to increase collagen content, dermal thickness and elasticity. Data on the effect of oestrogen on skin water content are also promising. Further, physiological studies on oestrogen and wound healing suggest that hormone replacement therapy (HRT) may play a ben...

Introduction T h e potential importance of oestrogens as antioxidant cardioprotectants is currently attracting considerable attention. Oestrogen is recognized to have a protective effect against coronary heart disease and its antioxidant action could contribute to the cardiovascular benefits observed on oestrogen administration in postmenopausal women [ 1,2]. This antioxidant-mediated cardiopro...

The term phyto-oestrogen encompasses isoflavone compounds, such as genistein and daidzein, found predominantly in soya products and the lignans, such as matairesinol and secoisolariciresinol, found in many fruits, cereals and in flaxseed. There is evidence that they have potential health benefits in man particularly against hormone-dependent diseases such as breast and prostate cancers and oste...