نتایج جستجو برای: odorant

تعداد نتایج: 3893  

2017
Feng Liu Zhou Chen Nannan Liu

As one of the most notorious ectoparasites, bed bugs rely heavily on human or animal blood sources for survival, mating and reproduction. Chemoreception, mediated by the odorant receptors on the membrane of olfactory sensory neurons, plays a vital role in their host seeking and risk aversion processes. We investigated the responses of odorant receptors to a large spectrum of semiochemicals, inc...

Journal: :Journal of neurochemistry 2006
Tatjana Abaffy Hiroaki Matsunami Charles W Luetje

Phylogenetic analysis groups mammalian odorant receptors into two broad classes and numerous subfamilies. These subfamilies are proposed to reflect functional organization. Testing this idea requires an assay allowing detailed functional characterization of odorant receptors. Here we show that a variety of Class I and Class II mouse odorant receptors can be functionally expressed in Xenopus lae...

Journal: :Cell 1997
Emily R Troemel Bruce E Kimmel Cornelia I Bargmann

Different olfactory cues elicit distinct behaviors such as attraction, avoidance, feeding, or mating. In the nematode C. elegans, these cues are sensed by a small number of olfactory neurons, each of which expresses several different odorant receptors. The type of behavioral response elicited by an odorant could be specified by the olfactory receptor or by the olfactory neuron in which the rece...

2016
Marco Paoli Andrea Anesi Renzo Antolini Graziano Guella Giorgio Vallortigara Albrecht Haase

The shape recognition model of olfaction maintains that odorant reception probes physicochemical properties such as size, shape, electric charge, and hydrophobicity of the ligand. Recently, insects were shown to distinguish common from deuterated isotopomers of the same odorant, suggesting the involvement of other molecular properties to odorant reception. Via two-photon functional microscopy w...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Marley D Kass Andrew H Moberly Michelle C Rosenthal Stephanie A Guang John P McGann

Long-term plasticity in sensory systems is usually conceptualized as changing the interpretation of the brain of sensory information, not an alteration of how the sensor itself responds to external stimuli. However, here we demonstrate that, in the adult mouse olfactory system, a 1-week-long exposure to an artificially odorized environment narrows the range of odorants that can induce neurotran...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Carrie L Iwema Hengsheng Fang Daniel B Kurtz Steven L Youngentob James E Schwob

Lesions of the olfactory periphery provide a means for examining the reconstitution of a diverse and highly regulated population of sensory neurons and the growth, en masse, of nascent axons to the bulb. The olfactory epithelium and its projection onto the bulb are reconstituted after ablation by methyl bromide gas, and some measure of olfactory function is restored. The extent to which the sys...

Journal: :Current Biology 2008
Shamik DasGupta Scott Waddell

A unifying feature of mammalian and insect olfactory systems is that olfactory sensory neurons (OSNs) expressing the same unique odorant-receptor gene converge onto the same glomeruli in the brain [1-7]. Most odorants activate a combination of receptors and thus distinct patterns of glomeruli, forming a proposed combinatorial spatial code that could support discrimination between a large number...

Journal: :Journal of neurophysiology 1997
N E Rawson G Gomez B Cowart J G Brand L D Lowry E A Pribitkin D Restrepo

Transduction mechanisms were investigated in human olfactory neurons by determining characteristics of odorant-induced changes in intracellular calcium concentration ([Ca2+]i). Olfactory neurons were freshly isolated from nasal biopsies, allowed to attach to coverslips, and loaded with the calcium-sensitive indicator fura-2. Changes in [Ca2+]i were studied in response to exposure to individual ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Sudeshna Das Madhumala K Sadanandappa Adrian Dervan Aoife Larkin John Anthony Lee Indulekha P Sudhakaran Rashi Priya Raheleh Heidari Eimear E Holohan Angel Pimentel Avni Gandhi Kei Ito Subhabrata Sanyal Jing W Wang Veronica Rodrigues Mani Ramaswami

Despite its ubiquity and significance, behavioral habituation is poorly understood in terms of the underlying neural circuit mechanisms. Here, we present evidence that habituation arises from potentiation of inhibitory transmission within a circuit motif commonly repeated in the nervous system. In Drosophila, prior odorant exposure results in a selective reduction of response to this odorant. B...

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