The present study was designed to investigate the ameliorative potential of Ocimum sanctum and its saponin rich fraction in chronic constriction injury-induced neuropathic pain in rats. The chronic constriction injury was induced by placing four loose ligatures around the sciatic nerve, proximal to its trifurcation. The mechanical hyperalgesia, cold allodynia, paw heat hyperalgesia and cold tai...

Healthy adult albino rats of either sex of Wistar strain weighing 150 to 250 g were used after approval of the Institutional Ethics Committee. They were kept on standard pellet diet and were allowed free access to food and water. The doses of antitubercular drugs (isoniazid (I)-27 mg/kg/day, rifampicin (R)-54 mg/kg/day, pyrazinamide (Z)-135 mg/kg/day) were extrapolated from daily human dose usi...

In the present review, an attempt has been made to congregate the botanical, phytochemical, ethnomedicinal, pharmacological and toxicological information on Ocimum sanctum Linn. (OS, Tulsi), a medicinal herb used in the indigenous system of medicine. OS has been adored in almost all ancient ayurvedic texts for its extraordinary medicinal properties. It is pungent and bitter in taste and hot, li...

UNLABELLED HISTORY AND OBJECTIVE: The aim of this study was to study the anxiolytic effects of Ocimum sanctum stress-induced anxiety. MATERIALS AND METHODS The study was carried out using male albino rats (200 ± 50 gm), male albino mice (25 ± 100) the effect of O. sanctum evaluated for anxiety and depression using forced swim test FST and rotarod test. RESULTS Restraint stress (3 hours/day ...

In the present study, leaves of Ocimum sanctum, Azadirachta indica and Phyllanthus amarus were collected and the collected leaves were shade dried and powdered by hand crushing. The preparations of different leaves extract was done through modified method. Three different solvents viz., methanol, chloroform and ethyl acetate were used to study the antimicrobial activity of herbal plants. Disc d...

The present study was conducted to investigate the effect of aqueous extracts of Ocimum sanctum L. leaves on blood glucose, serum lipid profile and anti-oxidative activity to protect various risk organs in DM rats. Ocimum sanctum L. leaves were extracted using water, then the total phenolic content was determined. Three groups of male Wistar rats were used including normal control rats, DM rats...

Ocimum sanctum fixed oil showed good antibacterial activity against Staphylococcus aureus, Bacillus pumilus and Pseudomonas aeruginosa, where S. aureus was the most sensitive organism. Sesame and soyabean oils also showed moderate activity against S. aureus. Higher content of linolenic acid in O. sanctum fixed oil could contribute towards its antibacterial activity. The antibacterial activity c...