نتایج جستجو برای: o6

تعداد نتایج: 2114  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Jennifer A Quinn Sara Xiaoyin Jiang James Carter David A Reardon Annick Desjardins James J Vredenburgh Jeremy N Rich Sridharan Gururangan Allan H Friedman Darell D Bigner John H Sampson Roger E McLendon James E Herndon Stevie Threatt Henry S Friedman

PURPOSE This phase II trial was designed to define the efficacy of Gliadel wafers in combination with an infusion of O6-benzylguanine (O6-BG) that suppresses tumor O6-alkylguanine-DNA alkyltransferase (AGT) levels in patients with recurrent glioblastoma multiforme for 5 days and to evaluate the safety of this combination therapy. EXPERIMENTAL DESIGN This was a phase II, open-label, single cen...

Journal: :Organic & biomolecular chemistry 2003
David M Hammond Dolorès Edmont Ana R Hornillo-Araujo David M Williams

The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.

Journal: :Nucleic acids research 1988
Y Yamagata K Kohda K Tomita

O6-Methylation of guanine residues in DNA can induce mutations by formation of base mispairing due to the deprotonation of N(1). The electronic, geometric and conformational properties of three N(9)-Substituted O6-methylguanine derivatives, O6-methyldeoxyguanosine (O6mdGuo), O6-methylguanosine (O6mGuo) and O6, 9-dimethylguanine (O6mdGua), were investigated by X-ray and/or NMR studies. O6mdGuo c...

Journal: :Journal of bacteriology 2002
Lubomir Grozdanov Ulrich Zähringer Gabriele Blum-Oehler Lore Brade Anke Henne Yuriy A Knirel Ursula Schombel Jürgen Schulze Ulrich Sonnenborn Gerhard Gottschalk Jörg Hacker Ernst T Rietschel Ulrich Dobrindt

Structural analysis of lipopolysaccharide (LPS) isolated from semirough, serum-sensitive Escherichia coli strain Nissle 1917 (DSM 6601, serotype O6:K5:H1) revealed that this strain's LPS contains a bisphosphorylated hexaacyl lipid A and a tetradecasaccharide consisting of one E. coli O6 antigen repeating unit attached to the R1-type core. Configuration of the GlcNAc glycosidic linkage between O...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011
Panagiotis Georgiadis Stella Kaila Paraskevi Makedonopoulou Eleni Fthenou Leda Chatzi Vasiliki Pletsa Soterios A Kyrtopoulos

BACKGROUND Investigations of the presence of the precarcinogenic DNA adduct O⁶-methylguanine (O6-meG) in humans and its association with exposure or cancer risk have been hindered by the absence of analytic methods of adequate sensitivity and throughput. We report the development, validation, and application of an ELISA-type assay for O6-meG appropriate for large-scale population studies. MET...

Journal: :Cancer research 1983
R Montesano H Brésil G Planche-Martel G P Margison A E Pegg

Repeated administration of dimethylnitrosamine (DMN) (2 mg/kg for 3 weeks) to BD IV rats results in an increased capacity for the liver to repair O6-methylguanine in DNA, whereas other DNA adducts (7-methylguanine and 3-methyladenine) are not affected. In the experiments reported here, data on the rapidity of action of the enhanced system, its capacity after different challenging doses of [14C]...

Journal: :The Journal of biological chemistry 1988
M S Satoh N Huh M F Rajewsky T Kuroki

DNA repair is essential for maintaining the integrity of the genetic material, and a number of DNA repair mechanisms have been fairly well characterized for the nuclear DNA of eukaryotic cells as well as prokaryotes. However, little is known about DNA repair in mitochondria. Using highly sensitive immunoanalytical methods to detect specific DNA alkylation products, we found active removal of O6...

Journal: :International journal of optics and photonics 2022

Detection of the O6-Carboxymethylguanine DNA Adduct in Colorectal Cancer Using a Graphene Field-Effect Transistor-Based Biosensors

Journal: :Organic letters 2000
Kotch Fettinger Davis

The lipophilic nucleoside, G 1, extracts Pb(2+) picrate from water into organic solvents to give structures based on the hydrogen-bonded G-quartet. Crystal structures indicate important differences between (G 1)(8)-Pb(2+) and (G 1)(8)-K(+). The divalent Pb(2+) templates a smaller G(8) cage than does K(+), as judged by the M-O6 bond length, O6-O6 diagonal distance, and inter-tetramer separation....

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