Abstract T his paper has considered the impact of unemployment on health capital in 136 countries during 2002–2010. The review of presented literature on health capital shows that the life expectancy has been considered as a proxy for health capital. Although, there are numerous studies that surveyed the mental and physical effects of unemployment, but there is no previous study in ou...

T herapies targeting the androgen receptor (AR) axis have constituted the Holy Grail in the management of advanced prostate cancer for seven decades. These hormonal therapies have traditionally taken two main forms: those that suppress gonadal androgen synthesis (e.g., the gonadotropin releasing hormone agonists/antagonists, such as leuprolide), and those that inhibit the AR directly (e.g., the...

Self-organising data mining is a new approach that supports the workflow process of a Knowledge Discovery more comprehensively and that targets on increasing both reliability and the predictive and descriptive power of generated models of ill-defined systems such as ecotoxicological systems. This paper reports results from applying a self-organising data mining to describe and predict carcinoge...

Only a minority of patients find a fully compatible donor for hematopoietic stem cell transplantation (HSCT). In the absence of human leukocyte antigen-matched related or unrelated donors, haploidentical donors (HAPLO) and umbilical cord blood and placental (UCB) cells are alternatives for patients with malignant and non-malignant hematological diseases. However, the risk of graft-versus-host d...

Acquired cytogenetic abnormalities in patients with acute myeloid leukemia (AML) are important independent predictors of response and survival. AML with normal karyotype (NK-AML) represents the largest cohort and is associated with intermediate risk. In NK-AML, distinct genomic abnormalities of the NPM1, CEBPA and FLT3 genes provide prognostic information. The European LeukemiaNet (ELN) propose...

ombination immunotherapy is emerging as a promising approach for the treatment of advanced prostate cancer. This research highlight discusses the combination of a PSA-directed poxviral vaccine and a monoclonal antibody blocking an important immune checkpoint molecule to treat men with metastatic castrationresistant prostate cancer. The results demonstrate feasibility and safety, as well as intr...

The sexual system of two peppermint shrimps, Lysmata bahia and Lysmata intermedia, inhabiting intertidal fossil coral terraces at Bocas del Toro, on the Caribbean coast of Panama, was examined. Dissections suggested that the population of each species consisted of functional males and functional simultaneous hermaphrodites. Males have cincinulli and appendices masculinae on the first and second...

Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic pre-malignant clonal condition which is diagnosed, often coincidentally, through high levels of immunoglobulin derived serum M-protein produced by a plasma cell clone. The prevalence of MGUS increases with age and it is some 3% at age 60 years and reaching close to 10% at age over 80 years. MGUS is a precursor conditio...