نتایج جستجو برای: nucleotide polymorphism
تعداد نتایج: 201089 فیلتر نتایج به سال:
abstract background von willebrand disease (vwd) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. the disease phenotype is due to quantitative and structural/functional defects in von willebrand factor (vwf) which is a glycoprotein with essential role as a carrier of fviii in circulation and also it serves the function as hemostasis regulator....
Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under the control of different genes. The precise genes influencing the different stages of the disease are not yet identified. The aim of the current study ...
Background and purpose: Hemophilia is a hereditary X-linked disorder. Females are carriers and males have the disorder. Hemophilia A is caused by deficiency in the production of factor VIII. In some hemophilia patients, inhibitors including IgG1 and IgG4 antibodies are expressed against this factor. These inhibitors interact with factor VIII and suppress its function. The current study aimed at...
Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...
Background: Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and a...
urokinase might play a role in the formation of kidney stones. this study was done to determine the association between +4065 t/c polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. this case-control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the baqiyatallah hospital of tehran in 2013. the study of polymorp...
conclusions lepr q223r polymorphisms may confer a significant risk of nafld and coronary atherosclerosis. the a allele in the k109r polymorphism might be considered an independent risk factor for coronary atherosclerosis in nafld patients. objectives to investigate the association of lepr polymorphisms at q223r and k109r with the risks of nafld and coronary atherosclerosis in the chinese han po...
مقدمه بیماری های چند عاملی یکی از مهمترین مباحث علوم زیستی می باشند که بدلیل تداخل عوامل محیطی و ژنتیکی به سختی از هم قابل تفکیک می باشند. سندرم متابولیک یکی از این بیماری ها است که ساز و کارهای دخیل در آن پیچیده هستند و عوامل ژنتیکی و محیطی جزء عوامل مهم در بیماریزایی این سندرم می باشند، بنابراین تعیین مدل برای بررسی این نوع بیماری ها ممکن نیست. یکی از راهکار ها جهت حل این معضل؛ استفاده از رو...
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