نتایج جستجو برای: nucleotide polymorphism

تعداد نتایج: 201089  

Journal: :iranian journal of pediatric hematology and oncology 0
mahbubeh nasiri department of biology, science and research branch, islamic azad university, fars, iran h galehdari department of genetics, university of shahid chamran, ahwaz, iran.سازمان اصلی تایید شده: دانشگاه آزاد اسلامی شیراز (islamic azad university of shiraz) m darbouy department of biology, science and research branch, islamic azad university, fars, iranسازمان اصلی تایید شده: دانشگاه شهید چمران (shahid chamran university) m yavarian hematology research centre,shiraz university of medical science, shiraz, iranسازمان اصلی تایید شده: دانشگاه آزاد اسلامی شیراز (islamic azad university of shiraz) b keikhaee thalassemia and hemoglobinopathies research center, ahwaz jondishapour university of medical sciences, ahwaz, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

abstract background von willebrand disease (vwd) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. the disease phenotype is due to quantitative and structural/functional defects in von willebrand factor (vwf) which is a glycoprotein with essential role as a carrier of fviii in circulation and also it serves the function as hemostasis regulator....

Journal: :Circulation: Cardiovascular Genetics 2009

Journal: :Nature Biotechnology 1998

Alexey A. Rudko Anna F. Garaeva Densema E. Gomboeva Dmitry Yu. Tsitrikov Elena Yu. Bragina Maxim B. Freidin Nadezhda P. Babushkina

Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under the control of different genes. The precise genes influencing the different stages of the disease are not yet identified. The aim of the current study ...

بوالحسنی, اعظم, سید میکائیلی, افسانه, نصوحی, نیکو,

Background and purpose: Hemophilia is a hereditary X-linked disorder. Females are carriers and males have the disorder. Hemophilia A is caused by deficiency in the production of factor VIII. In some hemophilia patients, inhibitors including IgG1 and IgG4 antibodies are expressed against this factor. These inhibitors interact with factor VIII and suppress its function. The current study aimed at...

Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...

Ghasemi N, Jahaninejad T Zaimy MA

Background: Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and a...

Journal: :biomacromolecular journal 0
neda assari department of cell and molecular biology, kharazmi university seiedabdolmajid angaji saeed morovvati department of molecular and biology, faculty of medical sciences, baghiyatallah university of medical sciences, tehran, iran

urokinase might play a role in the formation of kidney stones. this study was done to determine the association between +4065 t/c polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. this case-control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the baqiyatallah hospital of tehran in 2013. the study of polymorp...

Journal: :hepatitis monthly 0
bai-quan an department of gastroenterology, qingdao municipal college, nanjing medical university, qingdao, shandong province, china lin-lin lu digestive disease key laboratory of qingdao, qingdao, china; central laboratories, qingdao municipal hospital, qingdao, china chen yuan department of gastroenterology, qingdao municipal college, nanjing medical university, qingdao, shandong province, china yong-ning xin department of gastroenterology, qingdao municipal college, nanjing medical university, qingdao, shandong province, china; digestive disease key laboratory of qingdao, qingdao, china; department of gastroenterology, qingdao municipal hospital, qingdao, china; department of gastroenterology, qingdao municipal hospital, qingdao, china. tel: +86-53288905289, fax: +86-53288905293, e-mail:; shi-ying xuan, department of gastroenterology, qingdao municipal hospital, qingdao, china. tel: +86-53288905289, fax: +86-53288905293 shi-ying xuan department of gastroenterology, qingdao municipal college, nanjing medical university, qingdao, shandong province, china; digestive disease key laboratory of qingdao, qingdao, china; department of gastroenterology, qingdao municipal hospital, qingdao, china; department of gastroenterology, qingdao municipal hospital, qingdao, china. tel: +86-53288905289, fax: +86-53288905293, e-mail:; shi-ying xuan, department of gastroenterology, qingdao municipal hospital, qingdao, china. tel: +86-53288905289, fax: +86-53288905293

conclusions lepr q223r polymorphisms may confer a significant risk of nafld and coronary atherosclerosis. the a allele in the k109r polymorphism might be considered an independent risk factor for coronary atherosclerosis in nafld patients. objectives to investigate the association of lepr polymorphisms at q223r and k109r with the risks of nafld and coronary atherosclerosis in the chinese han po...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی اراک - دانشکده پزشکی اراک 1393

مقدمه بیماری های چند عاملی یکی از مهمترین مباحث علوم زیستی می باشند که بدلیل تداخل عوامل محیطی و ژنتیکی به سختی از هم قابل تفکیک می باشند. سندرم متابولیک یکی از این بیماری ها است که ساز و کارهای دخیل در آن پیچیده هستند و عوامل ژنتیکی و محیطی جزء عوامل مهم در بیماریزایی این سندرم می باشند، بنابراین تعیین مدل برای بررسی این نوع بیماری ها ممکن نیست. یکی از راهکار ها جهت حل این معضل؛ استفاده از رو...

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