While the reactive pocket of many enzymes has been shown to modify reactions of substrates by changing their chemical properties, examples of reactions whose stereochemical course is completely reversed are exceedingly rare. We report herein a class of water-soluble host assemblies that is capable of catalyzing the substitution reaction at a secondary benzylic carbon center to give products wit...

Nucleophilic ionic sources of fluoride are essential reagents in the synthetic toolbox to access high added-value fluorinated building blocks unattainable by other means. In this review, we provide a concise description and rationale outstanding features one these reagents, tetramethylammonium (TMAF), as well disclosing different methods for its preparation, how physicochemical properties solva...

An (amino)(phosphino) carbene can be transformed into (amino)(phosphonio) carbenes, which undergo nucleophilic intermolecular as well as intramolecular substitution reactions at the carbene center. A variety of carbenes can be synthesized starting from a single carbene precursor. The resulting gamut of electronic and steric effects possible should open the way not only to a detailed study of th...

Photoinduced nucleophilic substitution reactions of thirty p-nitrodiphenyl ethers including the herbicides nitrofen and chlornitrofen with a variety of amines were examined. The reaction took place by liberating nitrophenoxide or nitrite, depending on the substituents. Nitrofen liberated mainly nitrophenoxide by reactions with pyridine and 4methylpyridine to give N-phenylpyridinums, whereas chl...

Herein we report on the facile preparation of brominated SWCNTs based on two complementary reductive activation routes. The respective brominated SWCNTs are highly reactive and can be used in nucleophilic substitution reactions and represent versatile starting materials for the generation of sidewall functionalized SWCNTs with a high density of functional moieties.

Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted compounds. We developed efficient SNAr conditions for p-selective of polyfluoroarenes with phenothiazine in the presence a mild base afford corresponding 10-phenylphenothiazine (PTH) derivatives. The resulting polyfluoroarene-bearing PTH derivatives were subjected second reaction gene...