نتایج جستجو برای: nucleocytoplasmic shuttling

تعداد نتایج: 4663  

Journal: :Journal of cell science 2003
Agnes Roczniak-Ferguson Albert B Reynolds

P120-catenin is the prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins involved in cell-cell adhesion. Interestingly, all members of the p120 subfamily have also been observed in the nucleus, suggesting that they have additional roles that have yet to be determined. Here, we have developed a novel model system for studying the nucleocytoplasmic shuttling capabilit...

Journal: :American Journal of Physiology-Cell Physiology 2005

Journal: :The Journal of Cell Biology 2006
Victor Fok Kyle Friend Joan A. Steitz

The Epstein-Barr virus (EBV) noncoding RNAs, EBV-encoded RNA 1 (EBER1) and EBER2, are the most abundant viral transcripts in all types of latently infected human B cells, but their function remains unknown. We carried out heterokaryon assays using cells that endogenously produce EBERs to address their trafficking, as well as that of the La protein, because EBERs are quantitatively bound by La i...

Journal: :Journal of cell science 2007
Andreas Herrmann Michael Vogt Martin Mönnigmann Thomas Clahsen Ulrike Sommer Serge Haan Valeria Poli Peter C Heinrich Gerhard Müller-Newen

Persistent activation of the transcription factor STAT3 has been detected in many types of cancer and plays an important role in tumor progression, immune evasion and metastasis. To analyze persistent STAT3 activation we coexpressed STAT3 with v-Src. We found that tyrosine phosphorylation of STAT3 by v-Src is independent of Janus kinases (Jaks), the canonical activators of STATs. The STAT3-indu...

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