The use of heat treatment for the removal of non-specific effects in the direct radioimmunoassay of human circulatory CEA has been widely adopted have shown the existence of heat-labile determinants on CEA which may be destroyed by this assay technique. Heat-labile antigens appeared to be shared between CEA isolated from tumour and normal colon whilst the heat-stable antigens appeared to be mor...

NOTICE This DRAFT NTP Brief is distributed solely for the purpose of public comment and pre-dissemination peer review. It should not be construed to represent final NTP determination or policy.

This report describes the Simple Network Time Protocol (SNTP) Version 4, which is an adaptation of the Network Time Protocol (NTP) used to synchronize computer clocks in the Internet. SNTP can be used when the ultimate performance of the full NTP implementation described in RFC-1305 is not needed or justified. This report obsoletes RFC-1769, which describes SNTP Version 3. Its purpose is to cor...

The NTP network is an important part of the Internet’s infrastructure, and one of the most challenging times for the NTP network is around leap seconds. In this paper we look at the behaviour of public servers in the NTP network in 2005 and over the period from 2008 to present, focusing on leap seconds. We review the evolution of the NTP reference implementation with respect to leap seconds and...

The Network Time Protocol creates a network of hosts on the Internet that synchronize time. This paper describes the methods and results of a survey of the NTP network conducted by a “spider” that queried all findable NTP hosts on the Internet. This survey estimates the NTP network contains at least 175,000 hosts. An analysis of the survey data collects network size, timing, and topology inform...

Background The Nutrition Therapeutic Programme (NTP) involves the provision of food supplements at primary health clinics (PHCs) to correct nutritional deficiencies in vulnerable groups. Although previous studies have identified problems with implementing the programme at PHCs, assessments of its efficiency have been scarce. Objective To evaluate implementation of the NTP at PHCs that provide...

Chemical toxicology and carcinogenesis are dynamic disciplines, and the methodologies associated with these evaluations are under constant development and change. Accordingly, early in 1983, at the request of the National Toxicology Program (NTP), the NTP Board of Scientific Counselors established an Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation with Dr. John Doull (University ...

It has been reported recently that classical, isothermal-isobaric molecular dynamics (NTP MD) simulations at a time step of 1.00 fs of the standard-mass time (Δt=1.00 fssmt) and a temperature of ≤340 K using uniformly reduced atomic masses by tenfold offers better configurational sampling than standard-mass NTP MD simulations at the same time step. However, it has long been reported that atomic...

Nucleoside monophosphate prodrugs that are eventually bioconverted to the active nucleoside triphosphate (NTP) offer the potential to deliver increased intracellular NTP levels and/or organ-specific NTP enhancement. There are several classes of monophosphate prodrugs that have been applied to HCV drug discovery, and some of these approaches are currently being evaluated in humans. This review d...

In Plasma Medicine studies, the effect of non-thermal plasma (NTP) on biological targets is typically correlated with amount stable reactive oxygen and nitrogen species produced in a liquid medium. The NTP response target cellular redox mechanisms overlooked these investigations. Additionally, influence electrical properties cells physical neglected. Therefore, we used floating electrode dielec...