www.thoracic.org C LI P A N D C O P Y What causes NTM disease? NTM comprise more than 160 different species of bacteria that are found naturally in the environment. The existing species (types) of NTM can vary from place to place in the world. The most common species causing disease is called Mycobacterium avium complex. The next most common are Mycobacterium abscessus complex and Mycobacterium...

INTRODUCTION Several species of non-tuberculosis mycobacteria (NTM) can affect humans and can cause either symptomatic or asymptomatic infection.  This study aimed to determine the clinical and radiological manifestation, as well as the treatment, of M. simiae in patients in Masih Daneshvari Hospital, a TB referral hospital in Iran. METHODOLOGY This retrospective study involved all patients p...

We conducted a retrospective cohort study at six NTM treatment centres in North America and sought to evaluate tolerability of linezolid in NTM patients who were using linezolid prior to January 2013. All of the included patients either met the American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) criteria for pulmonary NTM disease or had extrapulmonary disease (defined ...

BACKGROUND In Italy, the prevalence of non-tuberculous mycobacteria (NTM) in human infections is largely unknown. Herein, we report the epidemiology of NTM infections in a region of central Italy, Tuscany, over the last 11 years, and provide a review of the recent literature on NTM isolation rates in different geographic regions. METHODS The complete collection of NTM strains isolated from a ...

BACKGROUND This study was specifically designed to develop a new 99mTc compound with 3-amino-4-[2-(2-methyl-5-nitro-1H-imidazol)-ethylamino]-4-oxo-butyrate (5-ntm-asp) and to verify whether this compound is feasible to be a radiopharmaceutical for hypoxic tumors. MATERIAL AND METHODS Metronidazole derivative 5-ntm-asp was synthesized and then radio-labeled by Na [99mTcO4], forming 99mTc-5-ntm-a...

BACKGROUND Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition. METHODS Data from patients with NTM-LD who participate...

In tuberculosis endemic areas, patients with sputum positive for acid-fast bacilli (AFB) are usually diagnosed and treated for pulmonary tuberculosis. The diagnosis of nontuberculous mycobacteria (NTM) lung disease is often ascertained only after lung disease progression occurs, increasing the risk of severe morbidity and mortality. We conducted a matched case-control study among a prospective ...

BACKGROUND Non-tuberculous mycobacteria (NTM) are important environmental pathogens capable of causing a spectrum of infection. The different species exhibit varied geographical prevalence worldwide. Identification of the infecting organism may be helpful in determining the clinical significance of the isolate. OBJECTIVE To describe the spectrum of NTM isolated from clinical specimens receive...

Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese wom...