DIABETES CARE, VOLUME 23, NUMBER 8, AUGUST 2000 Previous controlled trials comparing various insulin regimens in patients with type 2 diabetes poorly controlled with oral agents have shown that the simple addition of NPH insulin at bedtime (1–3) or of 70/30 premixed insulin (70% NPH insulin/ 30% regular insulin) before supper (4) to previous treatment with sulfonylureas alone (3,2), sulfonylure...

AIM Type 2 diabetes is associated with an increased risk of fractures. There are a few studies on the effects of diabetes treatment on fracture risk. The aim was to investigate the fracture risk related to various types of insulin therapy in primary care practices. METHODS Data from 105,960 type 2 diabetes patients from 1,072 general and internal medicine practices in Germany were retrospecti...

BACKGROUND The goal of this post hoc analysis was to determine key patient and treatment-related factors impacting glycosylated hemoglobin (A1C) and hypoglycemia in patients with uncontrolled type 2 diabetes who were initiated to basal insulin (neutral protamine Hagedorn [NPH] or glargine). METHODS Using individual patient-level data pooled from 6 treat-to-target trials, 2600 patients with ty...

BACKGROUND The prevalence of diabetes in women of childbearing age is increasing. As such, the number of pregnancies complicated by diabetes will inevitably increase. New insulin analogues such as the long-acting analogue insulin glargine may represent beneficial treatment options in pregnancy by ensuring that patients achieve excellent glycemic control without risk of maternal hypoglycemia. ...

The combination of oral antidiabetic drugs and bedtime insulin is currently regarded as the first-line therapy in type 2 diabetes. Repaglinide is an insulin secretatogue with a rapid onset and relatively short duration of action (1–3) that was developed for prandial glucose regulation. The prandial glucose regulation strategy attempts to synchronize availability of insulin to the physiological ...

OBJECTIVE To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Continuous glucose monitoring data were collected from a subset of patients (n = 90) who agreed to use a continuous glucose monitoring system d...

OBJECTIVES To evaluate the long-term cost-effectiveness of transferring type 2 diabetes patients to an insulin detemir regimen after failure to achieve adequate control with oral antidiabetic agents (OADs) alone, or in combination with neutral protamine hagedorn (NPH) insulin, or with insulin glargine in Germany. METHODS A computer simulation model of diabetes was used to make long-term proje...

According to Polish HTA guidelines, a systematic literature review was conducted in which data on comparative efficacy and safety of canagliflozin and NPH insulin were searched. As no head-to-head trial comparing canagliflozin with NPH insulin were identified, mixed treatment comparison analysis was conducted (following Polish HTA guidelines). Two RCTs assessing effectiveness of canagliflozin i...

OBJECTIVE To compare two subcutaneous insulin strategies for glycemic management of hyperglycemia in non-critically ill hospitalized patients with diabetes during enteral nutrition therapy (ENT). RESEARCH DESIGN AND METHODS Fifty inpatients were prospectively randomized to receive sliding-scale regular insulin (SSRI) alone (n = 25) or in combination with insulin glargine (n = 25). NPH insulin...

OBJECTIVE To assess usage patterns, effectiveness, andsafety of newly prescribed insulin treatment in patients with diabetes in Thailand MATERIAL AND METHOD Type 1 or type 2 diabetes mellitus patients who failed achievement of HbA1c <7%, and were about to start or switch to a new insulin treatment were enrolled into this prospective, longitudinal, multicenter observational study. Data regardi...