Noscapine (narcotine) is an opium alkaloid, isolated from Papaver somniferum L. Noscapine is being used in clinical trials for curing cancer. Till date researchers mainly discussed the erythro form of noscapine but in the present work the authors have discussed the erythro as well as threo form of noscapine. In the present work, library of 11 derivatives of noscapine from each of threoand eryth...

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

Background: Noscapine is a water soluble alkaloid with antitussive property and very less toxicity. It is obtained from the Papaveraceae family. Recently, new pharmacological properties such as anticancer, anti stroke and anti-angiogenic effects are introduced. There is no scientific report on noscapine effect on reproductive system. The aim of present study was to determine in vitro effect of ...

cal formula is C2H2307N. Actually Noscapine bears little resemblance to the narcotic alkaloids, either chemically or pharmacologically. The structure of morphine, codeine, and similar compounds is based on a phenanthrene nucleus, whereas Noscapine is an isoquinoline derivative (related to papaverine). It is readily absorbed after oral or parenteral administration, disappears rapidly from the bl...

The effect of naloxone, a non-selective opioid antagonist on some anxiolytic and analgesic drugs is reported. Noscapine is an opioid alkaloid with antitussive effect that cannot be antagonized by naloxone. The anxiolytic-like effect of noscapine has been shown in light-dark model and elevated plus maze. In this study the effect of naloxone on anxiolytic effect of noscapine in light-dark model w...

Graphical Abstract „A key experience in my career was the complete biosynthesis of opium poppy-derived noscapine yeast… I advise students to explore as much they can first years and focus deeply later years.“ Find out more about Sijin Li her Introducing… Profile.

Following surgery, the hormone dependence of breast tumors is exploited for therapy using antagonists such as tamoxifen, although occasional hormone-resistant clones do appear. Another chemotherapeutic strategy uses microtubule inhibitors such as taxanes. Unfortunately, these agents elicit toxicities such as leukocytopenia, diarrhea, alopecia, and peripheral neuropathies and are also associated...

We have shown previously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in humans. Structure-function analyses pointed to a proton at position-9 of the isoquinoline ring that can be modified without compromising tubulin binding activity. Thus, many noscapine analogs with different functional moieties at position...