Most anticancer drugs (epirubucin, adriamycin, bleomycin, vincristin, cyclophosphamide) exert their cytotoxic effect by free radicals-mediated mechanisms. The purpose of this study was to establish whether the antioxidants co-administered with epirubicin and cyclophosphamide reduce the adverse side effects of cytostatic chemotherapy without affecting their efficacy in dogs with spontaneous mamm...

Background: Type 2 diabetes (T2D) is known as a common chronic metabolic disease worldwide. Coronary artery diseases are one of the hazardous disorders in diabetic patients. The current study aimed to investigate the relationship between dietary antioxidants intake with insulin resistance and insulin sensitivity among T2D without and with coronary stenosis (CS). Methods: This case-control study...

Excessive production of reactive oxygen species (ROS) is a feature of human malignancy and is often triggered by activation of oncogenes such as activated Ras. ROS act as second messengers and can influence a variety of cellular process including growth factor responses and cell survival. We have examined the contribution of ROS production to the effects of N-Ras(G12D) and H-Ras(G12V) on normal...

Excessive production of reactive oxygen species (ROS) is a feature of human malignancy and is often triggered by activation of oncogenes such as activated Ras. ROS act as second messengers and can influence a variety of cellular process including growth factor responses and cell survival. We have examined the contribution of ROS production to the effects of N-RasG12D and H-RasG12V on normal hum...

OBJECTIVES This study explores the analytic implications of using questions about difficulty with daily activities that do not specify whether to consider assistance. METHODS For 1,054 Asset and Health Dynamics of the Oldest Old Study Wave 2 respondents, we compared responses to questions about difficulty without reference to assistance (ambiguous difficulty) to those about difficulty without...

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very transient species due to their high chemical reactivity that leads to lipid peroxidation and oxidation of DNA and proteins. Under normal conditions, antioxidant systems of the cell minimize the perturbations caused by ROS....

BACKGROUND Free radical mediated oxidative stress is mainly involved in the pathogenesis of diabetic complications. Proteins and lipids are among the prime targets for oxidative stress. In the present study, we evaluated the oxidative stress in chronic IDDM patients by estimating the lipid peroxidation, protein oxidation, and antioxidants status. SUBJECTS AND DESIGN A total of 35 (15 IDDM + 2...