Bleeding problems are associated with defects in platelet -granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized platelets from patients with ARC syndrome and observed reduced aggregation with ara...

Bleeding problems are associated with defects in platelet -granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized platelets from patients with ARC syndrome and observed reduced aggregation with ara...

Purpose The serum complement component 3 (C3) concentration and clinical characteristics of age-related cataract (ARC) subjects were analyzed to evaluate whether serum C3 levels are correlated with ARC. Methods A total of 492 ARC patients and 466 normal subjects from the Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China, were consecutive...

A permutation group is said to be quasiprimitive if each of its nontrivial normal subgroups is transitive. A structure theorem for finite quasiprimitive permutation groups is proved, along the lines of the O'NanScott Theorem for finite primitive permutation groups. It is shown that every finite, non-bipartite, 2-arc transitive graph is a cover of a quasiprimitive 2-arc transitive graph. The str...

To test the hypothesis that deficient interleukin 2 (IL-2) secretion may underlie the impaired capacity of T cells from patients with Acquired Immunodeficiency Syndrome (AIDS) and the AIDS-related complex (ARC) to generate the macrophage-activating lymphokine, gamma interferon (IFN-gamma), we used five specific microbial antigens to examine IL-2 production. Mononuclear cells from only one of 32...

Using a high-throughput cell-based assay, we identified a nucleoside analogue 4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide (ARC), which has the properties of a general transcriptional inhibitor. Specifically, ARC inhibits the phosphorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongati...

PURPOSE The causal genes for congenital cataract are good candidates for the genetic susceptibility for age-related cataract (ARC). The aim of this study was to investigate association between the polymorphisms in the causal genes for congenital cataract and ARC in a Chinese population. Meanwhile, we performed the replication study for previous identified risk genes for ARC. METHODS We recrui...

Visual experience scales down excitatory synapses in the superficial layers of visual cortex in a process that provides an in vivo paradigm of homeostatic synaptic scaling. Experience-induced increases in neural activity rapidly upregulates mRNAs of immediate early genes involved in synaptic plasticity, one of which is Arc (activity-regulated cytoskeleton protein or Arg3.1). Cell biological stu...

Arc fault is one of the important reasons of electrical fires. In virtue of cross talk, randomness and weakness of series arc faults in low-voltage circuits, very few of techniques have been well used to protect loads from series arc faults. Thus, a novel detection method based on support vector machine is developed in this paper. If series arc fault occurs, high frequency signal energy in circ...