Background: Recent evidence has indicated a deterioration in reproductive health of men in many countries over the past few decades, particularly a decrease in semen quality and an increase in prevalence of prostate cancer. The human male has a relatively low fertility potential as compared to other mammals. Thus, the human male may be at greater risk from reproductive toxicants. For example, t...

BACKGROUND Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. AIM The aim of this review was to assess the studies that evaluated the rel...

Background: Arsenic as a heavy metal exerts malformation and changes in the reproductive system of men via induction of oxidative stress. We sought to investigate the impact of Vitamin C (Vit C), as a potent antioxidant, on sperm quality and testicular tissue in mice that received sodium arsenite. Methods and materials: NMRI mice were classified into four groups: control, sodium arsenite (7 mg...

INTRODUCTION Bisphenol A (BPA) and Nonylphenol (NP) have estrogen-like activity, and some of their adverse biological effects have been demonstrated. This study was designed to determine the association of plasma and tissue concentrations of BPA and NP and changes in the parameters of the reproductive system in rats. METHODS Male Wistar rats were administered three doses of BPA and NP (5, 25,...

In men chronic heavy drinking interferes with reproductive hormones which are responsible for sexual maturation, sperm development and fertility. Alcohol is directly toxic to the testes; causing reduced testosterone levels.The present study was designed with an aim to elucidate the effect of oxidative stress on plasma testosterone level and hypothalamic pituitary gonadal (HPG) axis function in ...

A 3×2 factorial experiment was conducted to evaluate the effects of dietary vitamin C, E and Zinc supplementation on growth, survival and reproduction of Oreochromis niloticus in hapa based system installed in earthern ponds for 5 months. The triplicate groups consisting 30 fish were fed three levels of vitamin C (0, 50 and 1250 mg kg diet), two levels of vitamin E (0, 600 mg kg diet). An addit...

The objective of present study was to investigate the effects of aqueous garlic extracts, vitamin E and N-acetylcysteine on lead-induced lipid peroxidation, changes in antioxidant defense system and semen quality in the rat testes. Twenty-five male rats were divided into five groups. Animals within different treatment groups were maintained on their respective diets for 35 days as follows: grou...

The effects of Tahitian noni juice (TNJ), vitamin C and vitamin E on male reproductive functions in cyclophosphamide-treated wistar rats were compared. Thirty five male wistar rats with mean body weight of 180 ± 24.3 g were randomly divided into five groups. Group one were treated with cyclophosphamide (50 mg/kg, i.p.) while, group two were treated with TNJ (10 ml/kg, i.p.) and cyclophosphamide...

Background: Diabetes mellitus (DM), primary or idiopathic, is a chronic disorder of the carbohydrate, lipid and protein metabolism, characterized through hyperglycemia and glycosuria. DM can involve male reproductive function at many levels. Vitamin C ( ascorbic acid) is one of necessary elements in human and mammalian diet that is very important in fertility. Vitamin C prevent from gamets dama...

BACKGROUND Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and seminal plasma. METHODS In our prospective study, a total of 1 010 subfertile men, aged from 18 to 50 years old, were enrolled from August 2012 through June 2015. Their obesity-asso...